Aspartic acid functionalized magnetic nanoparticles for enhanced internalization in tumoral cell

IF 2.1 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

Journal of the Australian Ceramic Society Pub Date : 2025-01-23 DOI:10.1007/s41779-024-01102-x

Ludmila Motelica, Geanina Voicu, Cristina Chircov, Adrian Vasile Surdu, Roxana Doina Trusca, Bogdan Stefan Vasile, Denisa Ficai, Ovidiu Cristian Oprea, Daciana Silvia Marta, Victor-Eduard Peteu, Maria Anghelache, Anton Ficai, Manuela Calin

{"title":"Aspartic acid functionalized magnetic nanoparticles for enhanced internalization in tumoral cell","authors":"Ludmila Motelica, Geanina Voicu, Cristina Chircov, Adrian Vasile Surdu, Roxana Doina Trusca, Bogdan Stefan Vasile, Denisa Ficai, Ovidiu Cristian Oprea, Daciana Silvia Marta, Victor-Eduard Peteu, Maria Anghelache, Anton Ficai, Manuela Calin","doi":"10.1007/s41779-024-01102-x","DOIUrl":null,"url":null,"abstract":"<div><p>The antitumoral activity, and in general, the biological activity is strongly altered by the low uptake of the active agents within the targeted cells. Therefore, lots of efforts have been made to ensure better cellular uptake by using specific carriers. In the present research we have obtained magnetic nanoparticles stabilized by polyethylene glycol (PEG) coating, and functionalized with aspartic acid, which is an important amino acid for protein synthesis and energy production in the body. Such decorated nanoparticles can be internalized by the tumoral cell due to their higher metabolic rate. The nanoparticles were used as a delivery system for antitumoral drugs as cisplatin, carboplatin or irinotecan in a Trojan Horse strategy. Based on the obtained results, it was found that aspartic acid can improve the internalization efficiency of the magnetic carriers after being loaded with antitumoral agents. The nanoparticles are quite stable, can reach and enter the mitochondria and organize around lipid vesicles in quite a high concentration, best results being obtained for the system loaded with cisplatin starting from 0.1 mg/mL.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"61 section","pages":"265 - 283"},"PeriodicalIF":2.1000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41779-024-01102-x.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Australian Ceramic Society","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s41779-024-01102-x","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, CERAMICS","Score":null,"Total":0}

引用次数: 0

Abstract

The antitumoral activity, and in general, the biological activity is strongly altered by the low uptake of the active agents within the targeted cells. Therefore, lots of efforts have been made to ensure better cellular uptake by using specific carriers. In the present research we have obtained magnetic nanoparticles stabilized by polyethylene glycol (PEG) coating, and functionalized with aspartic acid, which is an important amino acid for protein synthesis and energy production in the body. Such decorated nanoparticles can be internalized by the tumoral cell due to their higher metabolic rate. The nanoparticles were used as a delivery system for antitumoral drugs as cisplatin, carboplatin or irinotecan in a Trojan Horse strategy. Based on the obtained results, it was found that aspartic acid can improve the internalization efficiency of the magnetic carriers after being loaded with antitumoral agents. The nanoparticles are quite stable, can reach and enter the mitochondria and organize around lipid vesicles in quite a high concentration, best results being obtained for the system loaded with cisplatin starting from 0.1 mg/mL.

查看原文本刊更多论文

天冬氨酸功能化磁性纳米颗粒增强肿瘤细胞内化

抗肿瘤活性，一般来说，生物活性被靶向细胞内活性物质的低吸收所强烈改变。因此，许多努力已作出，以确保更好的细胞摄取，通过使用特定的载体。在目前的研究中，我们获得了由聚乙二醇（PEG）涂层稳定的磁性纳米颗粒，并与天冬氨酸功能化，天冬氨酸是体内蛋白质合成和能量生产的重要氨基酸。由于其较高的代谢率，这种修饰的纳米颗粒可以被肿瘤细胞内化。在特洛伊木马策略中，纳米颗粒被用作顺铂、卡铂或伊立替康等抗肿瘤药物的递送系统。在此基础上，我们发现天冬氨酸在负载抗肿瘤药物后可以提高磁性载体的内化效率。纳米颗粒稳定性好，可以到达并进入线粒体，并以较高的浓度在脂质囊泡周围组织，以0.1 mg/mL为载药浓度时效果最好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of the Australian Ceramic Society Materials Science-Materials Chemistry

CiteScore

3.70

自引率

5.30%

发文量

123

期刊介绍： Publishes high quality research and technical papers in all areas of ceramic and related materials Spans the broad and growing fields of ceramic technology, material science and bioceramics Chronicles new advances in ceramic materials, manufacturing processes and applications Journal of the Australian Ceramic Society since 1965 Professional language editing service is available through our affiliates Nature Research Editing Service and American Journal Experts at the author''s cost and does not guarantee that the manuscript will be reviewed or accepted