Acoustic Methods of Reagentless Medical Laboratory Diagnostics

IF 1.2 4区物理与天体物理 Q4 ACOUSTICS

Acoustical Physics Pub Date : 2025-05-21 DOI:10.1134/S1063771024602309

A. V. Klemina, S. N. Gurbatov, V. A. Klemin

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Abstract

Acoustic methods of nonreactive medical laboratory diagnostics were developed using the BIOM acoustic analyzer as a measuring device. The device contains two ultrasmall ultrasonic resonators (about 100 µL) in volume. The device’s microprocessor system controls two ultrathermostats and maintains temperatures in the resonators in the range 20–38°C with an accuracy of ± 0.005°C. The developed special software makes it possible to determine the acoustic characteristics (rate and absorption of ultrasound) in blood serum, whole blood, and plasma with a relative error of ±5 × 10^–4 in terms of speed of ultrasound and ±10^–2 in terms of ultrasound absorption. This made it possible to determine the total protein, protein fractions, parameters of the lipid spectrum, and apolipoproteins A1 and B, as well as the elastic properties of patients' erythrocytes in vitro.The article presents a flowchart of the acoustic analyzer, an algorithm for its functioning, describes acoustic methods for determining total protein, protein fractions, lipid spectrum, and apolipoproteins A1 and B in blood serum and the elasticity of erythrocytes in whole blood in vitro.

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无试剂医学实验室诊断的声学方法

使用BIOM声学分析仪作为测量装置，开发了无反应医学实验室诊断的声学方法。该装置包含两个体积约为100 μ L的超小型超声谐振器。该设备的微处理器系统控制两个超恒温器，并在20-38°C范围内保持谐振器的温度，精度为±0.005°C。开发的专用软件可测定血清、全血、血浆的声学特性（超声率和吸收），超声速度的相对误差为±5 × 10-4，超声吸收的相对误差为±10-2。这使得在体外测定患者红细胞的总蛋白、蛋白组分、脂质谱参数、载脂蛋白A1和B以及弹性特性成为可能。本文介绍了声学分析仪的流程图，其功能的算法，描述了测定血清中总蛋白、蛋白质组分、脂质谱和载脂蛋白A1和B的声学方法，以及体外全血中红细胞的弹性。

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来源期刊

Acoustical Physics 物理-声学

CiteScore

1.60

自引率

50.00%

发文量

审稿时长

3.5 months

期刊介绍： Acoustical Physics is an international peer reviewed journal published with the participation of the Russian Academy of Sciences. It covers theoretical and experimental aspects of basic and applied acoustics: classical problems of linear acoustics and wave theory; nonlinear acoustics; physical acoustics; ocean acoustics and hydroacoustics; atmospheric and aeroacoustics; acoustics of structurally inhomogeneous solids; geological acoustics; acoustical ecology, noise and vibration; chamber acoustics, musical acoustics; acoustic signals processing, computer simulations; acoustics of living systems, biomedical acoustics; physical principles of engineering acoustics. The journal publishes critical reviews, original articles, short communications, and letters to the editor. It covers theoretical and experimental aspects of basic and applied acoustics. The journal welcomes manuscripts from all countries in the English or Russian language.