Switchable biomolecule adsorption on 2D thermoresponsive poly(N-isopropylacrylamide)–coated gold nanowire array

IF 2.3 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2025-07-04 DOI:10.1007/s00396-025-05466-9

Mai Thi Tuyet Nguyen, Dung Tuan Nguyen

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Abstract

This work presents the development of AuNW@pNIPAM, a hybrid platform combining electron beam lithography (EBL)-fabricated gold nanowire arrays (AuNWs) with thermoresponsive poly(N-isopropylacrylamide) (pNIPAM) brushes. A functionalization strategy using aryl diazonium salts, developed in our group, enables the precise confinement of the pNIPAM brushes exclusively on the AuNWs via surface initiated atom transfer radical polymerization (SI-ATRP), achieving an optimized 9 nm polymer thickness. Temperature-induced changes in the hydration state of pNIPAM were characterized using atomic force microscopy (AFM) in liquid phase verus the temperature, revealing a significant collapse of the polymer layer above the lower critical solution temperature (LCST). Concurrently, UV–vis spectroscopy demonstrated a 7-nm red shift in localized surface plasmon resonance (LSPR) due to the phase transition and a 15-nm shift upon bovine serum albumin (BSA) adsorption showcasing enhanced plasmonic sensitivity for real-time biomolecular monitoring. The reversible temperature-controlled adsorption/desorption of BSA on the AuNW@pNIPAM surface highlights the potential of this hybrid platform for applications in biosensing, drug delivery, and other bio-interfacing technologies.

Graphical abstract

Abstract Image

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二维热响应型聚n -异丙基丙烯酰胺包覆金纳米线阵列上可切换生物分子的吸附

这项工作介绍了AuNW@pNIPAM的发展，这是一个结合电子束光刻（EBL）制造的金纳米线阵列（aunw）和热响应性聚n -异丙基丙烯酰胺（pNIPAM）刷的混合平台。我们小组开发的一种使用芳基重氮盐的功能化策略，可以通过表面引发原子转移自由基聚合（SI-ATRP）将pNIPAM刷精确地限制在aunw上，实现优化的9纳米聚合物厚度。利用原子力显微镜（AFM）表征了pNIPAM水化状态随温度的变化，发现在较低临界溶液温度（LCST）以上，聚合物层明显坍塌。同时，紫外-可见光谱显示，由于相变，局部表面等离子体共振（LSPR）发生了7 nm的红移，牛血清白蛋白（BSA）吸附发生了15 nm的红移，表明等离子体对实时生物分子监测的敏感性增强。在AuNW@pNIPAM表面的可逆温控吸附/解吸凸显了这种混合平台在生物传感、药物传递和其他生物界面技术中的应用潜力。图形抽象

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.