Faecalibacterium prausnitzii Indicates Healthspan and Lifespan in Nonhuman Primates

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-09-23 DOI:10.1016/j.jnha.2025.100690

Kylie Kavanagh , Taylor Sheridan , Ravichandra Vemuri , Aleaya Bowie , Darla DeStephanis , Shannon Kraniak , Elizabeth Burner , McKinley Santiago

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引用次数: 0

Abstract

Objective

To assess the relationship between fecal Faecalibacterium prausnitzii and health resiliency.

Design

Cohorts of nonhuman primates were evaluated prior to disease development for fecal abundances of Faecalibacterium prausnitzii.

Setting

Radiation-induced and spontaneously arising age-induced morbidity and mortality, including high rates of Type 2 diabetes.

Participants

Old world male and female nonhuman primates.

Measurements

Age, weight, glycemic indices, fecal total microbial loads and specific detection Faecalibacterium prausnitzii levels as measured by whole genome sequencing or polymerase chain reaction.

Results

Higher levels of fecal Faecalibacterium prausnitzii was observed in nonhuman primates that survived whole body irradiation, had longer lifespans, and were protected from future Type 2 diabetes diagnoses. Type 2 diabetes development further lowered Faecalibacterium prausnitzii levels. The mean effect size for differences in fecal abundance was 1.76 (95% confidence interval 0.03–3.50).

Conclusion

The abundance of the intestinal microbial species Faecalibacterium prausnitzii appears to be a strong candidate biomarker species for a preferred microbiome that predicts superior health resiliency and associated lifespan.

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prausnitzii粪杆菌表明非人灵长类动物的健康寿命和寿命

目的探讨粪便中prausnitzfaecalibacterium与健康恢复力的关系。设计在疾病发生前对非人类灵长类动物的粪便中prausnitzii粪杆菌的丰度进行评估。辐射诱发的和自发产生的年龄诱发的发病率和死亡率，包括2型糖尿病的高发病率。参与者来自世界雄性和雌性非人类灵长类动物。测量方法：sage、体重、血糖指数、粪便总微生物负荷及特异检测，采用全基因组测序或聚合酶链反应测定prausnitzii粪杆菌水平。结果在全身照射后存活的非人类灵长类动物粪便中观察到较高水平的prausnitzii粪杆菌，它们的寿命更长，并且可以保护它们免受未来2型糖尿病的诊断。2型糖尿病的发展进一步降低了prausnitzii粪杆菌的水平。粪便丰度差异的平均效应大小为1.76（95%可信区间为0.03-3.50）。结论prausnitzii粪杆菌（Faecalibacterium prausnitzii）肠道微生物物种的丰度似乎是一个强有力的候选生物标志物物种，预示着优越的健康弹性和相关寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.