Four-dimensional (4D) printing of naturally-derived hydroxyapatite nanocomposite-based scaffolds for biomedical applications: A review

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2025-09-22 DOI:10.1016/j.nanoso.2025.101550

Irfan Mohammad , Ashok Jeshurun , Bogala Mallikharjuna Reddy

{"title":"Four-dimensional (4D) printing of naturally-derived hydroxyapatite nanocomposite-based scaffolds for biomedical applications: A review","authors":"Irfan Mohammad , Ashok Jeshurun , Bogala Mallikharjuna Reddy","doi":"10.1016/j.nanoso.2025.101550","DOIUrl":null,"url":null,"abstract":"<div><div>Due to advancements in 4D printing (4DP) technology, bioprinted materials can have many functions and dynamic features. Occluders, stents, microneedles, wound closures, smart cell microenvironments, implants, and drug delivery systems, are some examples of biomedical objects that have been manufactured using 4DP peocess. Due to similarity to bioapatite, hydroxyapatite nanocomposites (HAp NCs) are promising biomaterials in tissue engineering. Conventionally, bone/tissue engineering has extensively used HAp NCs due to their osteogenic and biocompatible qualities. However, traditional HAp production procedures restrict their extensive application in fabrication of biomedical materials, including bones, teeth, cartilage, etc. Novel techniques like 4DP have been used to create customized HAp NC–based scaffolds for the patients. In this review, we provide an overview of different 4DP methods that are utilized in the HAp NC-based scaffolds fabrication. Various natural sources of HAp and different synthesis methods have been investigated. Several 4DP HAp NC-based scaffolds, their properties, biomedical applications, advantages, disadvantages, and future prospects are discussed.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"44 ","pages":"Article 101550"},"PeriodicalIF":5.4500,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352507X25001209","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}

引用次数: 0

Abstract

Due to advancements in 4D printing (4DP) technology, bioprinted materials can have many functions and dynamic features. Occluders, stents, microneedles, wound closures, smart cell microenvironments, implants, and drug delivery systems, are some examples of biomedical objects that have been manufactured using 4DP peocess. Due to similarity to bioapatite, hydroxyapatite nanocomposites (HAp NCs) are promising biomaterials in tissue engineering. Conventionally, bone/tissue engineering has extensively used HAp NCs due to their osteogenic and biocompatible qualities. However, traditional HAp production procedures restrict their extensive application in fabrication of biomedical materials, including bones, teeth, cartilage, etc. Novel techniques like 4DP have been used to create customized HAp NC–based scaffolds for the patients. In this review, we provide an overview of different 4DP methods that are utilized in the HAp NC-based scaffolds fabrication. Various natural sources of HAp and different synthesis methods have been investigated. Several 4DP HAp NC-based scaffolds, their properties, biomedical applications, advantages, disadvantages, and future prospects are discussed.

查看原文本刊更多论文

四维（4D）打印用于生物医学应用的天然羟基磷灰石纳米复合材料支架：综述

由于4D打印（4DP）技术的进步，生物打印材料可以具有许多功能和动态特征。闭塞器、支架、微针、伤口闭合、智能细胞微环境、植入物和药物输送系统是使用4DP工艺制造的生物医学对象的一些例子。羟基磷灰石纳米复合材料具有与生物磷灰石相似的特性，是一种在组织工程中应用前景广阔的生物材料。由于羟基磷灰石具有成骨性和生物相容性，骨/组织工程已广泛使用羟基磷灰石。然而，传统的羟基磷灰石生产工艺限制了其在生物医学材料（包括骨、牙、软骨等）制造中的广泛应用。像4DP这样的新技术已经被用于为患者创建定制的基于HAp nc的支架。在这篇综述中，我们提供了不同的4DP方法用于制备羟基磷酰胺纳米基支架的概述。人们研究了HAp的各种天然来源和不同的合成方法。综述了几种基于4DP羟基磷灰石的支架材料及其性能、生物医学应用、优缺点及未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .