Bioheat transfer simulations of cryoablation and their comparison with different optimization techniques for patient specific segmented liver tumor tissue

IF 5 2区工程技术 Q1 ENGINEERING, MECHANICAL

International Journal of Thermal Sciences Pub Date : 2025-09-22 DOI:10.1016/j.ijthermalsci.2025.110301

Sonam Tanwar , Lalhmingsangi Famhawite , Pooja Raj Verma

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引用次数: 0

Abstract

Segmentation of the liver tumor plays an essential role in successful treatment of tumors, as accurate segmentation measures the correct tumor size necessary for treatment planning. The study considered segmented liver tumor of a patient specific CT Image provided by IRCAD which is based on implemented Couinaud Segmentation. The segmented tumor is then extracted using the 3D Slicer. Cryosurgery has been performed numerically for the segmented liver tumor using software based on the finite element method known as COMSOL Multiphysics. Large irregular tumor requires multiple cryoprobes for efficient iceball coverage to freeze tumors. However, the random placement of the cryoprobes shows the need to optimize the placement of the cryoprobes. Comparison of numerical results has been done for random placement of cryoprobes with two optimization methods - (i)K-mean clustering, (ii) Bubble packing algorithm. The numerical results show the volume of tumor destroyed and the formation of an iceball for the placement of different cryoprobes that will help surgeons in deciding the optimal placement of cryoprobes required for pre-planning efficient cryosurgery.

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低温消融的生物传热模拟及其与不同优化技术对患者特异性肝肿瘤组织的比较

肝脏肿瘤的分割对肿瘤的成功治疗起着至关重要的作用，因为准确的分割测量了治疗计划所必需的正确肿瘤大小。该研究考虑了IRCAD提供的患者特异性CT图像的肝肿瘤分段，该图像基于实现的Couinaud分割。然后使用3D切片器提取分段的肿瘤。使用基于COMSOL Multiphysics有限元方法的软件对分段肝肿瘤进行了数值冷冻手术。大的不规则肿瘤需要多个冷冻探针，以实现有效的冰球覆盖来冷冻肿瘤。然而，低温探针的随机放置表明需要优化低温探针的放置。比较了两种优化方法（k -均值聚类和气泡填充算法）对冷冻探针随机放置的数值结果。数值结果显示了不同冷冻探针放置位置的肿瘤破坏体积和冰球的形成，这将有助于外科医生决定预先计划有效冷冻手术所需的冷冻探针的最佳放置位置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Thermal Sciences 工程技术-工程：机械

CiteScore

8.10

自引率

11.10%

发文量

531

审稿时长

55 days

期刊介绍： The International Journal of Thermal Sciences is a journal devoted to the publication of fundamental studies on the physics of transfer processes in general, with an emphasis on thermal aspects and also applied research on various processes, energy systems and the environment. Articles are published in English and French, and are subject to peer review. The fundamental subjects considered within the scope of the journal are: * Heat and relevant mass transfer at all scales (nano, micro and macro) and in all types of material (heterogeneous, composites, biological,...) and fluid flow * Forced, natural or mixed convection in reactive or non-reactive media * Single or multi–phase fluid flow with or without phase change * Near–and far–field radiative heat transfer * Combined modes of heat transfer in complex systems (for example, plasmas, biological, geological,...) * Multiscale modelling The applied research topics include: * Heat exchangers, heat pipes, cooling processes * Transport phenomena taking place in industrial processes (chemical, food and agricultural, metallurgical, space and aeronautical, automobile industries) * Nano–and micro–technology for energy, space, biosystems and devices * Heat transport analysis in advanced systems * Impact of energy–related processes on environment, and emerging energy systems The study of thermophysical properties of materials and fluids, thermal measurement techniques, inverse methods, and the developments of experimental methods are within the scope of the International Journal of Thermal Sciences which also covers the modelling, and numerical methods applied to thermal transfer.