Synthesis of chiral multi-hole polydopamine nanospheres for spectroscopic and electrochemical discrimination of tryptophan enantiomers

IF 4.1 3区化学 Q1 CHEMISTRY, ANALYTICAL

Journal of Electroanalytical Chemistry Pub Date : 2025-09-19 DOI:10.1016/j.jelechem.2025.119486

Junyao Li , Nan Shi , Chen Jin, Laidi Xu, Yong Kong

引用次数: 0

Abstract

Au nanoparticles (AuNPs) are adsorbed onto the surface of multi-hole polydopamine (mPDA) nanospheres, which are utilized for the covalent bonding of L-cysteine (L-Cys) as the chiral source. The obtained mPDA@AuNPs/L-Cys is applied in the spectroscopic and electrochemical discrimination of tryptophan (Trp) enantiomers. Due to the same rotatory direction of L-Cys and L-Trp, L-Trp is selectively combined with the mPDA@AuNPs/L-Cys, and thus the chiral discrimination of the Trp enantiomers can be successfully achieved. Chiral solid polydopamine (sPDA) nanospheres are also synthesized and used for the chiral discrimination of the Trp enantiomers, while the discrimination ability of the chiral sPDA is significantly lower than that of the chiral mPDA. The improved discrimination ability of the chiral mPDA can be ascribed to its unique multi-hole structure, which is in favour of combining more amount of AuNPs and L-Cys.

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手性多孔聚多巴胺纳米球的合成及其对色氨酸对映体的光谱和电化学鉴别

金纳米粒子（AuNPs）吸附在多孔聚多巴胺（mPDA）纳米球表面，作为手性源用于l -半胱氨酸（L-Cys）的共价结合。所得的mPDA@AuNPs/L-Cys用于色氨酸对映体的光谱和电化学鉴别。由于L-Cys和L-Trp的旋向相同，L-Trp选择性地与mPDA@AuNPs/L-Cys结合，从而成功地实现了对Trp对映体的手性鉴别。本文还合成了手性固体聚多巴胺（sPDA）纳米微球，并将其用于色氨酸对映体的手性识别，但手性sPDA的识别能力明显低于手性mPDA。手性mPDA识别能力的提高可归因于其独特的多孔结构，有利于结合更多数量的aunp和L-Cys。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Electroanalytical Chemistry 化学-电化学

CiteScore

7.80

自引率

6.70%

发文量

912

审稿时长

2.4 months

期刊介绍： The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied. Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.