Three-day blues after ecstasy/MDMA use: Evidence from a longitudinal and daily analysis in the European nightlife scene

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-09-12 DOI:10.1016/j.drugalcdep.2025.112881

Matthijs Blankers , Ruben van Beek , Desirée Spronk , Wouter den Hollander , Rosa Andree , Tom P. Freeman , Meryem Grabski , H. Valerie Curran , Jon Waldron , Margriet W. van Laar

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引用次数: 0

Abstract

Background

There is a lack of understanding of the nature of the post-acute affective response in the days after ecstasy/3,4-Methylenedioxymethamphetamine (MDMA) use and whether this is associated with ecstasy/MDMA use or circumstantial factors. In the three days following ecstasy/MDMA use, we evaluated whether a drop in mental well-being is observed and can be related to ecstasy use.

Methods

Data for this study were obtained from a longitudinal and momentary analysis in the European nightlife scene (ALAMA study). Using ecological daily assessment, participants were asked to complete a daily 3-minute questionnaire for 35 days. Young adults (age 18–34) from the United Kingdom (n = 120) and the Netherlands (n = 124) who use ecstasy/MDMA were recruited in the nightlife scene and using social media campaigns. Substance use, psychological well-being and pathology, sleep quality, harm reduction behaviours, and socio-demographics data were collected digitally through a smartphone app.

Results

Participants reported on average a significant drop in mental well-being in the three days following ecstasy/MDMA use (B=-0.14, SE=0.04, p < .001) even when accounting for other substance use, socio-demographics, applied harm reduction strategies, measures of depression, anxiety and sleep quality. For commonly used substances other than ecstasy/MDMA and cocaine, no significant associations with mental well-being in the three days following their use were found.

Conclusions

A drop in mental well-being in the three days following ecstasy/MDMA use was associated with ecstasy/MDMA use, in addition to other factors such as (co-)use of other substances, especially cocaine, sleep duration and quality in the days following use, and baseline levels of depression and anxiety.

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使用摇头丸/摇头丸后三天的忧郁：来自欧洲夜生活场景的纵向和日常分析的证据

背景：对于使用摇头丸/3,4-亚甲基二氧甲基苯丙胺（MDMA）后几天内急性后情感反应的性质，以及这是否与摇头丸/MDMA使用或环境因素有关，目前还缺乏了解。在使用摇头丸/MDMA后的三天里，我们评估了是否观察到精神健康的下降，以及是否与摇头丸的使用有关。方法本研究的数据来自欧洲夜生活场景的纵向和瞬时分析（ALAMA研究）。使用生态每日评估，参与者被要求在35天内每天完成一份3分钟的问卷调查。来自英国（n = 120）和荷兰（n = 124）使用摇头丸/MDMA的年轻人（18-34岁）在夜生活现场和社交媒体活动中被招募。通过智能手机应用程序以数字方式收集物质使用、心理健康和病理、睡眠质量、减少伤害行为和社会人口统计数据。结果参与者报告在使用摇头丸/MDMA后三天内平均心理健康水平显著下降(B=-0.14， SE=0.04, p <；001)即使考虑到其他物质使用、社会人口统计学、应用的减少伤害策略、抑郁、焦虑和睡眠质量的测量。对于除摇头丸/MDMA和可卡因以外的常用物质，在使用后三天内没有发现与心理健康的显著关联。结论使用摇头丸/MDMA后3天内精神幸福感下降与使用摇头丸/MDMA有关，其他因素包括（共同）使用其他物质，特别是可卡因，使用后几天的睡眠时间和质量，以及抑郁和焦虑的基线水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.