The Progressive Supranuclear Palsy Clinical Deficits Scale accurately reflects functional as well as patient- and caregiver-reported outcomes

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-09-21 DOI:10.1016/j.parkreldis.2025.108060

Yi Zhe Lim , Su Juen Ngim , Jeremy Christopher Fernandiz , Alfand Marl F. Dy Closas , Tzi Shin Toh , Anis Nadhirah Khairul Anuar , Emily Siew Wen Chang , Johnny Jun Wei Cheok , Yi Wen Tay , Hans Xing Ding , Jie Ping Schee , Grace Sze Ern Chu , Lei Cheng Lit , Ai Huey Tan , Shen-Yang Lim

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Abstract

Background

Progressive supranuclear palsy (PSP) is a common atypical parkinsonian disorder, but a significant gap in clinical and research practice has been the unavailability until very recently of a brief but accurate scale to rate its clinical severity. The 7-item PSP Clinical Deficits Scale (PSP-CDS) offers an efficient method to evaluate PSP clinical severity and can be administered relatively rapidly. However, further validation of this new tool is needed.

Methods

Patients with PSP (n = 110; 55.5 % with Richardson syndrome [PSP-RS]) were consecutively recruited at a quaternary centre in Malaysia. We examined the correlations between the PSP-CDS and measures of patients’ functional status, using the Barthel Index (which is generic, brief, and clinician rated) and the Cortical Basal ganglia Functional Scale (CBFS; which is disease-specific, more comprehensive, and patient/caregiver reported).

Results

There were strong correlations between the PSP-CDS vs. the Barthel Index (r_s = −0.81) and the CBFS (r_s = 0.64) (both P < 0.001). In a post hoc analysis of individual items of the PSP-CDS and Barthel Index and CBFS, significant (and also mostly strong) correlations were observed, in the motor as well as non-motor domains.

Conclusions

The strong correlations between PSP disease severity as measured by the PSP-CDS vs. generic and disease-specific measures of functional status, rated by clinicians and patients and caregivers, provide further support for the PSP-CDS as a valid and efficient instrument. More widespread use of such tools can help to address the global gap of inadequate phenotyping of patients in routine clinical and research practice.

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进行性核上性麻痹临床缺陷量表准确地反映了功能以及患者和护理人员报告的结果

进行性核上性麻痹（PSP）是一种常见的非典型帕金森病，但在临床和研究实践中存在重大差距，直到最近才有一个简短而准确的量表来评估其临床严重程度。7项PSP临床缺陷量表（PSP- cds）提供了一种评估PSP临床严重程度的有效方法，并且可以相对快速地实施。然而，需要进一步验证这个新工具。方法在马来西亚的一家第四医学中心连续招募PSP患者（n = 110； 55.5%为理查德森综合征[PSP- rs]）。我们使用Barthel指数（通用的、简短的、临床医生评定的）和皮质基底神经节功能量表（CBFS，疾病特异性的、更全面的、由患者/护理人员报告的）来检验PSP-CDS与患者功能状态测量之间的相关性。结果PSP-CDS与Barthel指数（rs = - 0.81）和CBFS （rs = 0.64）有很强的相关性（P < 0.001）。在PSP-CDS、Barthel指数和CBFS的个别项目的事后分析中，在运动和非运动领域观察到显著的（而且大多数是强的）相关性。结论PSP- cds测量的PSP疾病严重程度与临床医生、患者和护理人员评定的功能状态的通用和疾病特异性测量之间存在强相关性，进一步支持PSP- cds作为一种有效和高效的工具。更广泛地使用这些工具可以帮助解决常规临床和研究实践中患者表型不充分的全球差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.