Rare presentation of Behçet's disease in a 22-year-old male with combined retinal artery and vein occlusions

Q3 Medicine

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-17 DOI:10.1016/j.ajoc.2025.102434

Brennan Isaac , Ahmad Rehmani , Lee Angioletti

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引用次数: 0

Abstract

Purpose

To demonstrate how the systemic work-up of a combined retinal and vein occlusion (CRAVO) led to a diagnosis of Behcet's disease.

Observations

A 22-year-old male presented with sudden, profound vision loss in the left eye upon waking up. Presenting visual acuity was no light perception (NLP) in the left eye and fundus examination revealed findings consistent with both central retinal artery and vein occlusion. Laboratory workup for common infectious etiologies was negative; however, inflammatory markers were elevated. Further testing revealed human leukocyte antigen (HLA)∗B51 positivity as well as a patent foramen ovale (PFO) that was found on echocardiogram. The patient was initiated on high dose steroids and immunosuppressants for Behçet's Disease and underwent surgical closure of PFO.

Conclusions and importance

This study highlights the value of a proper diagnostic approach in patients presenting with CRAVO without suspected risk factors. Investigation of autoimmune, genetic, cardiologic, and inflammatory diseases led to the diagnosis of Behçet's Disease, an uncommon condition where timely recognition and early treatment can prevent further vision loss and reduce the risk of future vascular events.

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罕见的behaperet病的表现，22岁的男性合并视网膜动脉和静脉闭塞

目的：展示视网膜和静脉联合闭塞（CRAVO）的系统检查如何导致白塞病的诊断。一位22岁的男性在醒来时突然出现左眼严重视力丧失。表现为左眼无光感（NLP），眼底检查显示视网膜中央动脉和静脉闭塞。常见感染性病因的实验室检查呈阴性；然而，炎症标志物升高。进一步检查显示人白细胞抗原(HLA) * B51阳性，超声心动图显示卵圆孔未闭（PFO）。患者开始使用大剂量类固醇和免疫抑制剂治疗behaperet病，并接受手术关闭PFO。结论和重要性本研究强调了正确诊断方法对无可疑危险因素的CRAVO患者的价值。对自身免疫性、遗传性、心脏病学和炎症性疾病的调查导致behet病的诊断，这是一种罕见的疾病，及时识别和早期治疗可以预防进一步的视力丧失并降低未来血管事件的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Ophthalmology Case Reports Medicine-Ophthalmology

CiteScore

2.40

自引率

0.00%

发文量

513

审稿时长

16 weeks

期刊介绍： The American Journal of Ophthalmology Case Reports is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished case report manuscripts directed to ophthalmologists and visual science specialists. The cases shall be challenging and stimulating but shall also be presented in an educational format to engage the readers as if they are working alongside with the caring clinician scientists to manage the patients. Submissions shall be clear, concise, and well-documented reports. Brief reports and case series submissions on specific themes are also very welcome.