Mesoporous Potassium-Based Metal–Organic Framework as a Drug Carrier

IF 10.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Bo Fang, , , Tianyu Shan, , , Sailing Chen, , , Fei Pan, , , Xue Yang, , , Ding Xiao, , , Feihe Huang*, , and , Zhengwei Mao*, 
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Abstract

To date, the number of reported mesoporous metal–organic frameworks (MOFs) remains limited. Herein, we report a novel mesoporous potassium-based MOF (K-MOF), designated as KMOF-1, whose precise structure was determined by using single-crystal X-ray diffraction. KMOF-1 used 18-crown-6 units as the organic linkers and potassium ions as the metal centers, forming a framework topological structure with interconnected four-membered rings. The specific surface area of the synthesized KMOF-1 was determined by the Brunauer–Emmett–Teller method, which showed a high specific surface area of 1034 m2/g. KMOF-1 was demonstrated to be a promising drug carrier, exhibiting encapsulation capabilities for various drugs and maintaining stability for a defined period under simulated physiological conditions. Using vascular endothelial growth factor (VEGF) aptamers as model drugs, we further confirmed the effective loading of VEGF aptamers in KMOF-1 (KMOF-1@VEGF) and the ability of KMOF-1@VEGF to release VEGF aptamers responsively in acidic environments. Additionally, in vitro studies showed that KMOF-1 protected VEGF aptamers from degradation by nucleases, allowing them to be effectively taken up by cells. This novel K-MOF, with its biocompatible metal centers, mesoporous channels, and demonstrated efficacy as a drug carrier, offers a significant advancement in developing MOF-based drug delivery systems.

The mesoporous structure, high drug loading capacity, and biocompatibility of KMOF-1 make it a promising candidate for biomedical applications.

介孔钾基金属-有机骨架作为药物载体
迄今为止,报道的介孔金属有机框架(mof)的数量仍然有限。本文报道了一种新型介孔钾基MOF (K-MOF),命名为KMOF-1,通过单晶x射线衍射测定了其精确结构。KMOF-1以18冠6单元为有机连接体,以钾离子为金属中心,形成四元环相互连接的框架拓扑结构。用brunauer - emmet - teller法测定了合成的KMOF-1的比表面积,其比表面积高达1034 m2/g。KMOF-1被证明是一种很有前途的药物载体,具有对多种药物的包封能力,并在模拟生理条件下保持一定时间的稳定性。以血管内皮生长因子(VEGF)适体作为模型药物,我们进一步证实了KMOF-1中VEGF适体的有效负载(KMOF-1@VEGF)以及KMOF-1@VEGF在酸性环境下响应性释放VEGF适体的能力。此外,体外研究表明,KMOF-1保护VEGF适体免受核酸酶的降解,使其有效地被细胞吸收。这种新型K-MOF具有生物相容性金属中心、介孔通道和作为药物载体的有效性,为开发基于mof的药物传递系统提供了重大进展。KMOF-1的介孔结构、高载药能力和生物相容性使其成为生物医学应用的一个有前景的候选材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Central Science
ACS Central Science Chemical Engineering-General Chemical Engineering
CiteScore
25.50
自引率
0.50%
发文量
194
审稿时长
10 weeks
期刊介绍: ACS Central Science publishes significant primary reports on research in chemistry and allied fields where chemical approaches are pivotal. As the first fully open-access journal by the American Chemical Society, it covers compelling and important contributions to the broad chemistry and scientific community. "Central science," a term popularized nearly 40 years ago, emphasizes chemistry's central role in connecting physical and life sciences, and fundamental sciences with applied disciplines like medicine and engineering. The journal focuses on exceptional quality articles, addressing advances in fundamental chemistry and interdisciplinary research.
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