{"title":"Mesoporous Potassium-Based Metal–Organic Framework as a Drug Carrier","authors":"Bo Fang, , , Tianyu Shan, , , Sailing Chen, , , Fei Pan, , , Xue Yang, , , Ding Xiao, , , Feihe Huang*, , and , Zhengwei Mao*, ","doi":"10.1021/acscentsci.5c00904","DOIUrl":null,"url":null,"abstract":"<p >To date, the number of reported mesoporous metal–organic frameworks (MOFs) remains limited. Herein, we report a novel mesoporous potassium-based MOF (K-MOF), designated as <b>KMOF-1</b>, whose precise structure was determined by using single-crystal X-ray diffraction. <b>KMOF-1</b> used 18-crown-6 units as the organic linkers and potassium ions as the metal centers, forming a framework topological structure with interconnected four-membered rings. The specific surface area of the synthesized <b>KMOF-1</b> was determined by the Brunauer–Emmett–Teller method, which showed a high specific surface area of 1034 m<sup>2</sup>/g. <b>KMOF-1</b> was demonstrated to be a promising drug carrier, exhibiting encapsulation capabilities for various drugs and maintaining stability for a defined period under simulated physiological conditions. Using vascular endothelial growth factor (VEGF) aptamers as model drugs, we further confirmed the effective loading of VEGF aptamers in <b>KMOF-1</b> (<b>KMOF-1@VEGF</b>) and the ability of <b>KMOF-1@VEGF</b> to release VEGF aptamers responsively in acidic environments. Additionally, in vitro studies showed that <b>KMOF-1</b> protected VEGF aptamers from degradation by nucleases, allowing them to be effectively taken up by cells. This novel K-MOF, with its biocompatible metal centers, mesoporous channels, and demonstrated efficacy as a drug carrier, offers a significant advancement in developing MOF-based drug delivery systems.</p><p >The mesoporous structure, high drug loading capacity, and biocompatibility of <b>KMOF-1</b> make it a promising candidate for biomedical applications.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1651–1658"},"PeriodicalIF":10.4000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00904","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Central Science","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acscentsci.5c00904","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
To date, the number of reported mesoporous metal–organic frameworks (MOFs) remains limited. Herein, we report a novel mesoporous potassium-based MOF (K-MOF), designated as KMOF-1, whose precise structure was determined by using single-crystal X-ray diffraction. KMOF-1 used 18-crown-6 units as the organic linkers and potassium ions as the metal centers, forming a framework topological structure with interconnected four-membered rings. The specific surface area of the synthesized KMOF-1 was determined by the Brunauer–Emmett–Teller method, which showed a high specific surface area of 1034 m2/g. KMOF-1 was demonstrated to be a promising drug carrier, exhibiting encapsulation capabilities for various drugs and maintaining stability for a defined period under simulated physiological conditions. Using vascular endothelial growth factor (VEGF) aptamers as model drugs, we further confirmed the effective loading of VEGF aptamers in KMOF-1 (KMOF-1@VEGF) and the ability of KMOF-1@VEGF to release VEGF aptamers responsively in acidic environments. Additionally, in vitro studies showed that KMOF-1 protected VEGF aptamers from degradation by nucleases, allowing them to be effectively taken up by cells. This novel K-MOF, with its biocompatible metal centers, mesoporous channels, and demonstrated efficacy as a drug carrier, offers a significant advancement in developing MOF-based drug delivery systems.
The mesoporous structure, high drug loading capacity, and biocompatibility of KMOF-1 make it a promising candidate for biomedical applications.
期刊介绍:
ACS Central Science publishes significant primary reports on research in chemistry and allied fields where chemical approaches are pivotal. As the first fully open-access journal by the American Chemical Society, it covers compelling and important contributions to the broad chemistry and scientific community. "Central science," a term popularized nearly 40 years ago, emphasizes chemistry's central role in connecting physical and life sciences, and fundamental sciences with applied disciplines like medicine and engineering. The journal focuses on exceptional quality articles, addressing advances in fundamental chemistry and interdisciplinary research.