All roads lead to TDP43: Convergent mechanisms of TDP43 autoregulation.

IF 6.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-09-23 DOI:10.1083/jcb.202508101

Morgan R Miller,Sami J Barmada

引用次数: 0

Abstract

TDP43 is an essential RNA-binding protein with fundamental ties to neurodegenerative disorders. In this issue, Hasegawa-Ogawa and colleagues (https://doi.org/10.1083/jcb.202406097) describe a new mechanism for regulating TDP43 function, involving alternatively spliced variants that inhibit TDP43 via dominant-negative activity.

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条条大路通TDP43: TDP43自动调节的趋同机制

TDP43是一种重要的rna结合蛋白，与神经退行性疾病有着根本的联系。在这一期中，Hasegawa-Ogawa及其同事（https://doi.org/10.1083/jcb.202406097）描述了一种调节TDP43功能的新机制，涉及通过显性负活性抑制TDP43的选择性剪接变体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.