{"title":"Advances in physical and chemical strategies for dentin hypersensitivity therapy","authors":"Xinru Li, Qihui Wang, Yirong Sun, Guoliang Wang, Congxiao Zhang, Jianxun Ding","doi":"10.1016/j.jare.2025.09.041","DOIUrl":null,"url":null,"abstract":"<h3>Background</h3>Dentin hypersensitivity (DH) is a prevalent and acute dental pain disorder marked by a brief yet sharp toothache caused by exposed dentin, often in response to thermal, chemical, and mechanical stimuli. It significantly affects a person’s quality of life, interfering with routine activities, such as eating and drinking. With an improved understanding of the mechanisms underlying DH, various physical and chemical strategies have been developed to alleviate the condition.<h3>Aim of the review</h3>This review evaluates three principal mechanistic theories underlying DH desensitization, including the Direct Innervation Hypothesis, the Odontoblast Receptor Theory, and the Hydrodynamic Theory. It provides a detailed analysis of current physical, chemical, and synergistic therapeutic methods used for desensitization. Additionally, it discusses potential future therapeutic approaches for the treatment of DH.<h3>Key scientific concepts of review</h3>This review highlights recent advancements and ongoing challenges in applying physical and chemical strategies for DH treatment. It also discusses potential future strategies and methods, offering insights into the prospects for the field.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"40 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Research","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.jare.2025.09.041","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Dentin hypersensitivity (DH) is a prevalent and acute dental pain disorder marked by a brief yet sharp toothache caused by exposed dentin, often in response to thermal, chemical, and mechanical stimuli. It significantly affects a person’s quality of life, interfering with routine activities, such as eating and drinking. With an improved understanding of the mechanisms underlying DH, various physical and chemical strategies have been developed to alleviate the condition.
Aim of the review
This review evaluates three principal mechanistic theories underlying DH desensitization, including the Direct Innervation Hypothesis, the Odontoblast Receptor Theory, and the Hydrodynamic Theory. It provides a detailed analysis of current physical, chemical, and synergistic therapeutic methods used for desensitization. Additionally, it discusses potential future therapeutic approaches for the treatment of DH.
Key scientific concepts of review
This review highlights recent advancements and ongoing challenges in applying physical and chemical strategies for DH treatment. It also discusses potential future strategies and methods, offering insights into the prospects for the field.
期刊介绍:
Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences.
The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.