Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020–2023

IF 6.6 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-09-22 DOI:10.3201/eid3110.250191

Janet Perry, Tal Rakler, Katya Arnold, Anat Wiseman, Cinthia Satuchne, Yaniv Pima, Galina Moiseeva, Ilana Maler, Eugenia Yakunin, Assaf Rokney, Ehud Elnekave

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引用次数: 0

Abstract

Salmonella enterica serovar Muenchen emerged in Israel in 2018 and became a major public health threat. We aimed to determine the role of poultry in rising human cases, transmission routes within the broiler industry, and genetic similarity to Salmonella Muenchen found globally. We used whole-genome sequencing to compare Salmonella Muenchen isolates from poultry, food, and humans collected in Israel (2020–2023; n = 109) and globally (n = 125). Salmonella Muenchen sequence type 82 isolates from Israel harbored pESI plasmid, exhibited high genetic similarity between human and poultry sources, and closely resembled international pESI-positive strains; we found quinolone-resistance determinants in 58.6% of isolates. Prevalence in commercial broiler flocks was 61.5% (95% CI 51.5%–71.5%); strains could not be traced to breeder flocks, but on-farm persistence existed. The clonal spread of Salmonella Muenchen in poultry contributes to increased incidence in humans. Horizontal transmission in broilers requires control measures to protect public health.

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家禽和人的多药耐药肠沙门氏菌血清型Muenchen序列82型，以色列，2020-2023

2018年，以色列出现了大肠沙门氏菌血清型Muenchen，并成为一种主要的公共卫生威胁。我们的目的是确定家禽在不断上升的人类病例中的作用，肉鸡行业内的传播途径，以及与全球发现的慕尼黑沙门氏菌的遗传相似性。我们使用全基因组测序比较了在以色列（2020-2023年，n = 109）和全球（n = 125）收集的从家禽、食品和人身上分离的Muenchen沙门氏菌。以色列Muenchen序列82型分离菌携带pESI质粒，人、禽源遗传相似性高，与国际pESI阳性菌株相似；我们在58.6%的分离株中发现喹诺酮耐药决定因素。商品肉鸡群患病率为61.5% (95% CI为51.5% ~ 71.5%)；菌株不能追溯到种鸡群，但在农场存在持久性。慕尼黑沙门氏菌在家禽中的克隆性传播导致了人类发病率的增加。肉鸡的水平传播需要控制措施以保护公众健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.