Is tumor shape associated with molecular diagnosis, extent of resection, or postoperative focal deficits in diffuse low-grade gliomas?

IF 4.1 Q1 CLINICAL NEUROLOGY

Neuro-oncology advances Pub Date : 2025-08-19 eCollection Date: 2025-01-01 DOI:10.1093/noajnl/vdaf138

Claes Johnstad, Ingerid Reinertsen, Alba Corell, Erik Thurin, Tora Dunås, Margret Jensdottir, Jiri Bartek, Klas Holmgren, Rickard L Sjöberg, Francesco Latini, Maria Zetterling, Rupavathana Mahesparan, Peter Milos, Björn Sjögren, Henrietta Nittby Redebrandt, Gregor Tomasevic, Lars Kjelsberg Pedersen, Asgeir S Jakola, Ole Solheim

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Abstract

Background: This study aimed to explore the potential association between tumor shape, 1p/19q codeletion, EOR, and new postoperative focal deficits in patients with diffuse low-grade glioma.

Methods: We analyzed data from 225 WHO grade 2 glioma surgeries performed in nine centers in Norway and Sweden. The tumor measurements were based on automatic segmentations of preoperative T2/FLAIR MRI scans by Raidionics. Contact surface area (CSA) was defined as the area between the tumor and brain parenchyma and was estimated by subtracting the surface area covered by the dura from the total surface area. The sphericity index (SI) was defined as the quotient of the tumor surface area and the surface area of a sphere with equal volume. Focal deficits were defined as any new motor, language, or visual deficits postoperatively.

Results: The univariable analyses showed that a larger CSA was associated with higher age (P = .02), lower EOR (P < .0001), and more focal deficits (P = .005) but not with 1p/19q codeletion (P = .54). A higher SI was associated with higher age (P = .02) and lower EOR (P < .0001) but not with focal deficits (P = .08) or 1p/19q codeletion (P = .90). The multivariable linear regression model supported the univariable associations between EOR and CSA (P = .0003) and SI (P = .0013), respectively. Contrarily, the logistic regression model showed that focal deficits were associated with SI (P = .014) but not with CSA (P = .056).

Conclusion: The tumor shape appears to be independently associated with EOR and new focal deficits but not with molecular diagnosis in patients with low-grade glioma.

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弥漫性低级别胶质瘤的肿瘤形状是否与分子诊断、切除程度或术后局灶缺损相关？

背景：本研究旨在探讨弥漫性低级别胶质瘤患者肿瘤形状、1p/19q编码、EOR和术后新发局灶缺损之间的潜在关联。方法：我们分析了挪威和瑞典9个中心进行的225例WHO二级胶质瘤手术的数据。肿瘤测量基于术前T2/FLAIR MRI扫描的Raidionics自动分割。接触表面积（Contact surface area， CSA）定义为肿瘤与脑实质之间的面积，通过从总表面积中减去硬脑膜覆盖的表面积来估算。球度指数（SI）定义为肿瘤表面积与等体积球体表面积之商。局灶性缺陷被定义为术后任何新的运动、语言或视觉缺陷。结果：单变量分析显示CSA越大与年龄越高相关(P =。02)， EOR降低（P = 0.005），但与1p/19q编码无关（P = 0.54）。较高的SI与较高的年龄（P = 0.02）、较低的EOR （P = 0.08）或1p/19q编码（P = 0.90）相关。多变量线性回归模型支持EOR与CSA （P = 0.0003）和SI （P = 0.0003）之间的单变量相关性。分别为0013)。相反，逻辑回归模型显示局灶性缺陷与SI相关（P = 0.014），而与CSA无关（P = 0.056）。结论：低级别胶质瘤患者的肿瘤形状与EOR和新的局灶缺损独立相关，而与分子诊断无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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