Confronting the Antimicrobial Resistance Crisis in China: Emerging Superbugs, Genomic Surveillance, and Innovative Countermeasures.

Abstract

The antimicrobial resistance (AMR) crisis in China has escalated into a critical public health threat. Extensive antibiotic use in both clinical and agricultural settings has created strong selective pressures, promoting the emergence of resistant strains and accelerating their dissemination. This increasing threat is exemplified by the rapid spread of multidrug-resistant bacteria. Consequently, genomic surveillance of these pathogens and the development of effective countermeasures are urgently needed. In this paper, we highlight three critical dimensions of the AMR challenge in China, which include the recent emergence of resistant bacteria, genomic surveillance efforts, and progress in the development of novel antimicrobial agents. By synthesizing recent research on the evolutionary dynamics of drug-resistant pathogens in China and outlining innovative antimicrobial strategies, this study provides insights to guide evidence-based antimicrobial stewardship programs.