Liver Functions in Patients with Chronic Liver Disease and Liver Cirrhosis: Correlation of FLIS and LKER with PALBI Grade and APRI.

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Ahmet Cem Demirşah, Elif Gündoğdu
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引用次数: 0

Abstract

Introduction: In chronic liver disease (CLD) and liver cirrhosis (LC), assessing hepatic function and disease severity is crucial for patient management. This study aimed to evaluate the relationship between platelet-albumin-bilirubin (PALBI) grade and aspartate aminotransferase/platelet ratio index (APRI) with the functional liver imaging score (FLIS) and liver-to-kidney enhancement ratio (LKER) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced hepatobiliary phase (HBP) magnetic resonance imaging (MRI).

Methods: After applying exclusion criteria, 86 patients with CLD or LC who underwent Gd-EOB-DTPA-enhanced MRI between January 2018 and October 2023 were included. APRI and PALBI grades were calculated from laboratory data. FLIS was determined as the sum of three HBP imaging features (liver parenchymal enhancement, biliary excretion, and portal vein sign), with each scoring 0-2. LKER was calculated by dividing liver signal intensity by kidney intensity using region of interest (ROI) measurements. Spearman's correlation was used to assess relationships between the variables.

Results: APRI showed a weak negative correlation with both FLIS (r = -0.327, p = 0.02) and LKER (r = -0.308, p = 0.004). PALBI showed a moderate negative correlation with FLIS (r = -0.495, p = 0.001) and LKER (r = -0.554, p = 0.0001).

Discussion: FLIS and LKER moderately correlated with PALBI and weakly with APRI. LKER may be a more practical tool due to its quantitative nature. Despite limitations, combining imaging and lab-based scores could enhance liver function assessment.

Conclusion: FLIS and LKER can validate, rather than predict or exclude, liver dysfunction in CLD and LC.

慢性肝病和肝硬化患者的肝功能:FLIS和LKER与PALBI分级和APRI的相关性
在慢性肝病(CLD)和肝硬化(LC)中,评估肝功能和疾病严重程度对患者管理至关重要。本研究旨在利用钆乙氧基苄基二乙烯三胺五乙酸(Gd-EOB-DTPA)增强肝胆期(HBP)磁共振成像(MRI)技术,评价血小板-白蛋白-胆红素(PALBI)分级和天冬氨酸转氨酶/血小板比值指数(APRI)与肝脏功能成像评分(FLIS)和肝肾增强比(LKER)的关系。方法:根据排除标准,纳入2018年1月至2023年10月期间接受gd - eob - dtpa增强MRI检查的86例CLD或LC患者。APRI和PALBI评分根据实验室数据计算。FLIS被确定为三个HBP影像学特征(肝实质增强、胆汁排泄和门静脉征象)的总和,每个特征评分为0-2分。LKER通过使用感兴趣区域(ROI)测量将肝脏信号强度除以肾脏强度来计算。Spearman相关被用来评估变量之间的关系。结果:APRI与FLIS (r = -0.327, p = 0.02)、LKER (r = -0.308, p = 0.004)呈弱负相关。PALBI与FLIS (r = -0.495, p = 0.001)、LKER (r = -0.554, p = 0.0001)呈中度负相关。讨论:FLIS和LKER与PALBI中度相关,与APRI弱相关。由于LKER的定量性质,它可能是一个更实用的工具。尽管有局限性,结合影像学和实验室评分可以增强肝功能评估。结论:FLIS和LKER可以验证,而不是预测或排除CLD和LC的肝功能障碍。
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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
246
审稿时长
1 months
期刊介绍: Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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