Ocular and systemic immune profiles associated with cystoid macular edema in retinitis pigmentosa.

IF 0.9
Frontiers in ophthalmology Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI:10.3389/fopht.2025.1653404
Yan Tao, Huanyu Zhao, Sakurako Shimokawa, Masatoshi Fukushima, Kohta Fujiwara, Takahiro Hisai, Kaho Yamamoto, Ayako Okita, Koh-Hei Sonoda, Yusuke Murakami
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Abstract

Purpose: We aimed to investigate the local and systemic inflammatory profiles associated with cystoid macular edema (CME) in patients with retinitis pigmentosa (RP).

Patients and methods: Paired aqueous humor and serum samples were collected at the time of cataract surgery from 37 eyes of 37 patients with typical RP, including 29 without CME and eight with CME. The concentrations of cytokines and chemokines were determined using a multiplexed immunoassay (Q-Plex). Group comparisons were conducted to assess differences in the inflammatory molecule levels between the RP patients with and without CME. Correlations among the intraocular parameters, the systemic inflammatory molecules, and the CME status were analyzed.

Results: Compared to RP patients without CME, those with CME showed significantly increased aqueous levels of interleukin 23 (IL-23) (p = 0.002), I-309 (p = 0.039), and growth-related oncogene alpha (GROα) (p = 0.042). A multiple-factor analysis further supported a potential association between CME formation and an IL-23-related inflammatory network characterized by aqueous IL-23, IL-8, GROα, eotaxin, I-309, serum IL-23, and IFN-γ.

Conclusion: These findings suggest that both intraocular and systemic immune activation may play a role in the development of CME in patients with RP. Specifically, IL-23-driven inflammation may be associated with macular fluid accumulation. Further longitudinal studies in larger cohorts are necessary to elucidate these relationships and explore their clinical implications.

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色素性视网膜炎中与黄斑囊样水肿相关的眼部和全身免疫特征。
目的:我们旨在研究色素性视网膜炎(RP)患者与囊样黄斑水肿(CME)相关的局部和全身炎症特征。患者和方法:在37例典型RP患者白内障手术时收集37只眼的房水和血清成对样本,其中29例无CME, 8例有CME。使用多重免疫分析法(Q-Plex)测定细胞因子和趋化因子的浓度。进行组间比较,以评估合并和不合并CME的RP患者炎症分子水平的差异。分析眼内参数、全身炎症分子和CME状态之间的相关性。结果:与没有CME的RP患者相比,CME患者的白介素23 (IL-23) (p = 0.002)、I-309 (p = 0.039)和生长相关癌基因α (GROα) (p = 0.042)的水样水平显著升高。多因素分析进一步支持CME形成与IL-23相关炎症网络之间的潜在关联,该炎症网络以水相IL-23、IL-8、GROα、eotaxin、I-309、血清IL-23和IFN-γ为特征。结论:这些发现提示眼内和全身免疫激活可能在RP患者CME的发展中起作用。具体来说,il -23驱动的炎症可能与黄斑积液有关。需要在更大的队列中进行进一步的纵向研究来阐明这些关系并探索其临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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