Amlodipine use during pregnancy: Current status in the medical care field in Argentina.

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Hipertension y Riesgo Vascular Pub Date : 2025-09-20 DOI:10.1016/j.hipert.2025.04.003

M P Pérez, A M Ghelfi, G Miranda, M A Del Sueldo, J M Zilberman, L S Voto, A Delucchi, P Rodriguez, N F Renna

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引用次数: 0

Abstract

Introduction: Calcium channel blockers (CCBs), such as nifedipine, are commonly used to treat hypertensive disorders of pregnancy (HDP). With the withdrawal of Nifedipine-RETARD and the limitations in compounding formulations, the off-label use of amlodipine (AML) has increased. The primary objective of this study was to describe the frequency of AML use, while the secondary objective was to outline the professional profile of the surveyed physicians.

Materials and methods: A descriptive, observational, cross-sectional study conducted in 2024 using closed digital surveys. The target population included physicians of both sexes involved in the care of HDP in Argentina, with access to electronic devices and the Internet. The survey was developed by the Working Group on Hypertension in Women of the Argentine Society of Hypertension (SAHA) and validated by experts. It was distributed through social networks and SAHA's email list.

Results: A total of 276 physicians were surveyed, with a mean age of 49.6±11.5 years, 46.6% of whom were women. Among the respondents, 213 (77.1%) used CCBs to treat HDP, and 176 (63.8%) reported prescribing AML. Of those prescribing AML, 51% were general practitioners, 12% cardiologists, 22% obstetrician-gynaecologists, and 14% belonged to other specialties. The initial dose reported was 5mg/day in 82.4% of cases. The main reasons cited for not prescribing AML were lack of experience (44.4%) and perceived insufficient scientific evidence (28.9%).

Conclusions: The use of AML was frequent, with 6 out of 10 surveyed physicians reporting its use.

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妊娠期间氨氯地平的使用：阿根廷医疗保健领域的现状。

钙通道阻滞剂（CCBs），如硝苯地平，通常用于治疗妊娠期高血压疾病（HDP）。随着硝苯地平- retard的退出和复方制剂的限制，氨氯地平（AML）的超说明书使用有所增加。本研究的主要目的是描述AML使用的频率，而次要目的是概述被调查医生的专业概况。材料和方法：一项描述性、观察性、横断面研究，于2024年使用封闭的数字调查进行。目标人群包括参与阿根廷HDP护理的男女医生，他们可以使用电子设备和互联网。该调查由阿根廷高血压学会（SAHA）妇女高血压工作组制定，并经专家验证。它通过社交网络和SAHA的电子邮件列表分发。结果：共调查276名医师，平均年龄49.6±11.5岁，女性占46.6%。在受访者中，213名（77.1%）使用CCBs治疗HDP， 176名（63.8%）报告使用AML。在开AML处方的患者中，51%是全科医生，12%是心脏病专家，22%是妇产科医生，14%属于其他专业。82.4%的病例报告的初始剂量为5mg/天。不开AML处方的主要原因是缺乏经验（44.4%）和认为科学证据不足（28.9%）。结论：AML的使用较为频繁，10位受访医生中有6位报告使用过AML。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hipertension y Riesgo Vascular Medicine-Internal Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

39 days

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