Janelle Sloychuk, Jin Soo Song, Lin Fu Zhu, Adrian Mendez, Jillian Querney, David Côté
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引用次数: 0
Abstract
Background: With ongoing investigations to improve facial nerve recovery after injury, brief electrical stimulation (BES) and platelet-rich plasma (PRP) application have become promising modalities. The usage of combined modalities has not yet been investigated. We aimed to evaluate differences in facial nerve regeneration between rats receiving BES (group 1) and rats receiving BES plus PRP (group 2) following transection and primary neurorrhaphy.
Methods: This was a prospective randomized animal study of 2 groups of 6 rats that underwent facial nerve transection and repair at the main trunk of the nerve. Both groups received BES on postoperative day 0 for 1 hour using an implantable stimulation device, with group 2 additionally receiving concurrent PRP. The primary measure of whisker amplitude was recorded from 2 to 8 weeks postoperatively.
Results: At week 2, the average whisker amplitude for groups 1 and 2 was 6.5 and 2.0 degrees, respectively. At week 4, group 1 remained unchanged at 6.1 degrees, whereas group 2 improved to 10.1 degrees. By 6 weeks, average amplitudes were 8.2 and 14.0 degrees, respectively. By week 8, measures were 9.8 and 16.7 degrees, respectively. All results were statistically significant (P < 0.05).
Conclusions: Application of BES and PRP following neurorrhaphy in a rat model yields a greater effect than BES alone in expediting facial nerve recovery.
期刊介绍：
Plastic and Reconstructive Surgery—Global Open is an open access, peer reviewed, international journal focusing on global plastic and reconstructive surgery.Plastic and Reconstructive Surgery—Global Open publishes on all areas of plastic and reconstructive surgery, including basic science/experimental studies pertinent to the field and also clinical articles on such topics as: breast reconstruction, head and neck surgery, pediatric and craniofacial surgery, hand and microsurgery, wound healing, and cosmetic and aesthetic surgery. Clinical studies, experimental articles, ideas and innovations, and techniques and case reports are all welcome article types. Manuscript submission is open to all surgeons, researchers, and other health care providers world-wide who wish to communicate their research results on topics related to plastic and reconstructive surgery. Furthermore, Plastic and Reconstructive Surgery—Global Open, a complimentary journal to Plastic and Reconstructive Surgery, provides an open access venue for the publication of those research studies sponsored by private and public funding agencies that require open access publication of study results. Its mission is to disseminate high quality, peer reviewed research in plastic and reconstructive surgery to the widest possible global audience, through an open access platform. As an open access journal, Plastic and Reconstructive Surgery—Global Open offers its content for free to any viewer. Authors of articles retain their copyright to the materials published. Additionally, Plastic and Reconstructive Surgery—Global Open provides rapid review and publication of accepted papers.
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