{"title":"Assessing the Impact of Methodological Assumptions on Estimated Age of Disease-Causal Human Papillomavirus Infection in US Females.","authors":"Alhaji Cherif, Xuedan You, John Cook, Miriam Reuschenbach, Ya-Ting Chen, Craig Roberts, Ruifeng Xu","doi":"10.1093/ofid/ofaf548","DOIUrl":null,"url":null,"abstract":"<p><p>We adapted a previous discrete event simulation model to assess the impact of varying time distributions from disease-causal human papillomavirus (HPV) infection to CIN2+ onset on the estimated age distribution of disease-casual infection in the United States. Differences in these assumptions had minimal effect on estimates, underscoring the importance of expanded HPV vaccination.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf548"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448938/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofaf548","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We adapted a previous discrete event simulation model to assess the impact of varying time distributions from disease-causal human papillomavirus (HPV) infection to CIN2+ onset on the estimated age distribution of disease-casual infection in the United States. Differences in these assumptions had minimal effect on estimates, underscoring the importance of expanded HPV vaccination.
期刊介绍:
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.