Impact of a 24-Week Workplace Physical Activity Program on Oxidative Stress Markers, Metabolic Health, and Physical Fitness: A Pilot Study in a Real-World Academic Setting.

IF 2.5 Q1 SPORT SCIENCES
Gabriele Maisto, Maria Scatigna, Simona Delle Monache, Maria Francesca Coppolino, Lorenzo Pugliese, Anna Maria Sponta, Loreta Tobia, Elio Tolli, Pierfrancesco Zito, Valerio Bonavolontà, Leila Fabiani, Chiara Tuccella, Maria Giulia Vinciguerra
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Abstract

Background: Previous studies showed that workplace physical activity programs (WPAPs) could improve general health among employees. However, there is a lack of correlation between oxidative redox status and the metabolic and physical fitness (PF) of workers. The objective of the study was to evaluate the improvements of a 24-week combined circuit training and mobility training program on PF, oxidative redox status, and metabolic parameters on healthy academic employees. Methods: Twenty-six university employees (52.8 ± 11.5 years) followed a 24-week WPAP composed of two circuit training sessions and one mobility training session per week. PF components were assessed through one leg stand, shoulder/neck mobility, handgrip, dynamic sit-up, jump and reach, and 2-Minute step test (2MST). Oxidative stress and antioxidant potential were evaluated through derived-Reactive Oxygen Metabolites (d-ROM) and biological antioxidant potential (BAP) tests, respectively. Metabolic measurements included total cholesterol, LDL-C, HDL-C, triglycerides, and fasting plasma glucose. All assessments were conducted at baseline and after 24 weeks. Results: D-ROM values increased significantly likely due to an acute adaptive response to exercise and a stable BAP/d-ROM ratio was maintained. At baseline, subjects with higher 2MST scores showed a better BAP/d-ROM ratio compared to those with lower 2MST scores, which was also associated with normal weight status (p < 0.05), healthy values of triglycerides (p < 0.01), and LDL-C (p < 0.01). Excluding statin-treated subjects, an intriguing shift toward a condition of enhanced antioxidant capacity was observed. Conclusions: Overall, the 24-week WPAP improved metabolic health and maintained redox balance, despite increased reactive oxygen species (ROS) production. Statin supplementation may have hidden antioxidant adaptations to physical exercise, an intriguing observation that warrants further studies.

为期24周的工作场所体育活动计划对氧化应激标志物、代谢健康和身体健康的影响:一项在现实世界学术环境中的试点研究
背景:以前的研究表明,工作场所体育活动计划(wpap)可以改善员工的总体健康状况。然而,氧化氧化还原状态与工人的代谢和身体健康(PF)之间缺乏相关性。本研究的目的是评估24周循环训练和运动训练计划对健康学术雇员的PF、氧化氧化还原状态和代谢参数的改善。方法:26名大学员工(52.8±11.5岁)接受为期24周的WPAP训练,包括每周2次循环训练和1次活动训练。通过单腿站立、肩/颈活动、握力、动态仰卧起坐、跳跃和伸展以及2分钟步幅测试(2MST)来评估PF成分。氧化应激和抗氧化潜能分别通过衍生活性氧代谢物(- d)和生物抗氧化潜能(BAP)测试进行评估。代谢测量包括总胆固醇、LDL-C、HDL-C、甘油三酯和空腹血糖。所有评估均在基线和24周后进行。结果:BAP/ - rom值明显升高,可能是由于对运动的急性适应性反应,BAP/ - rom比值保持稳定。在基线时,2MST评分较高的受试者BAP/ - d比高于2MST评分较低的受试者,这也与正常体重状态(p < 0.05)、甘油三酯健康值(p < 0.01)和LDL-C (p < 0.01)相关。排除他汀类药物治疗的受试者,观察到抗氧化能力增强的有趣转变。结论:总的来说,尽管活性氧(ROS)的产生增加,但24周的WPAP改善了代谢健康并维持了氧化还原平衡。他汀类药物补充剂可能对体育锻炼具有隐藏的抗氧化适应性,这一有趣的观察值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Functional Morphology and Kinesiology
Journal of Functional Morphology and Kinesiology Health Professions-Physical Therapy, Sports Therapy and Rehabilitation
CiteScore
4.20
自引率
0.00%
发文量
94
审稿时长
12 weeks
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