Oraltypes of the human oral bacteriome and mycobiome

IF 5.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-09-19 DOI:10.1016/j.jdent.2025.106119

Xu Wang , Xinming Zhang , Shuangshuang Wu , Zhimin Yan

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引用次数: 0

Abstract

Objectives

The inter‑individual variations in oral microbial composition remain largely unknown. This study aims to identify the bacterial and fungal compositional patterns of human oral microbiome.

Methods

A total of 389 bacterial samples from 5 cohorts and 118 fungal samples from 3 cohorts were collected. Partitioning around medoid (PAM) clustering method was used to cluster the samples of 16S and ITS amplification, respectively. Considering that the clusters identified in gut microbiome were previously named as “enterotypes”, the identified clusters in oral microbiome were called “oraltypes”.

Results

In the oral bacteriome, Prevotella, Streptococcus and Neisseria were the most abundant genera. Meanwhile, two bacterial “oraltypes” dominated by Neisseria and Veillonella were identified. In the oral mycobiome, Candida and Malassezia were the most abundant genera, which were also the dominant genera of the two identified fungal “oraltypes”. Further analysis showed that bacterial “oraltypes” were associated with the human age.

Conclusions

There are two bacterial and two fungal compositional patterns in human oral microbiome.

Clinical significance

This study identified the “oraltypes”, which can be used to depict the homogeneity and heterogeneity of oral microbiota among populations, as well as to analyze the susceptibility to certain diseases in different individuals.

查看原文本刊更多论文

口腔类型的人类口腔细菌群和真菌群。

目的：口腔微生物组成的个体间差异在很大程度上仍然未知。本研究旨在确定人类口腔微生物群的细菌和真菌组成模式。方法：收集5个队列共389份细菌样本和3个队列共118份真菌样本。采用PAM聚类方法对16S扩增样本和ITS扩增样本进行聚类。考虑到之前在肠道微生物组中鉴定的集群被命名为“肠型”，在口腔微生物组中鉴定的集群被称为“口腔型”。结果：口腔菌群中以普雷沃菌属、链球菌属和奈瑟菌属数量最多。同时，鉴定出以奈瑟氏菌和细孔菌为主的两种“口腔型”细菌。口腔真菌群落中，念珠菌属和马拉色菌属数量最多，也是鉴定的两种真菌“口腔型”的优势属。进一步分析表明，细菌的“口腔类型”与人类的年龄有关。结论：口腔微生物群存在两种细菌和两种真菌组成模式。临床意义：本研究确定了“口腔类型”，可用于描述人群口腔微生物群的同质性和异质性，分析不同个体对某些疾病的易感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.