Effect of Therapy Reminder Application on Treatment Adherence in Adults with Beta-Thalassemia Major: A Randomized Clinical Trial.

IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL
Fatemeh Mehrabadi, Mahdieh Arian, Zahra Badiee
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引用次数: 0

Abstract

Background: Non-adherence to treatment in patients with beta-thalassemia major (BTM) presents a significant challenge in effective disease management. This study aimed to assess the effect of a therapy reminder application (app) on treatment adherence in adult patients with BTM in Mashhad in 2024.

Methods: A randomized clinical trial was conducted in 2024 at a thalassemia clinic affiliated with Mashhad University of Medical Sciences (Mashhad, Iran). Participants were randomly assigned to the intervention and control groups, using permuted block randomization, with concealed allocation. The intervention group used the ThalaMe therapy reminder app for 8 weeks (February-July 2024), while the control group received standard care. Medication adherence was measured using the Morisky Medication Adherence Scale (MMAS-8) and the Chronic Disease Treatment Adherence Questionnaire (CDTAQ) before and after the intervention. Statistical analysis was conducted using SPSS software, using paired t tests or Wilcoxon signed-rank tests for within-group comparisons and independent t tests or Mann-Whitney U tests for between-group comparisons. P<0.05 was considered statistically significant.

Results: The study included 76 adult patients with BTM, equally distributed between the intervention and control groups (n=38 each). Baseline measurements showed no significant differences between groups in either MMAS-8 scores (P=0.75) or CDTAQ scores (P=0.11). The MMAS-8 was inversely scored, with lower scores indicating higher adherence. Following the 8-week intervention period, the group using the ThalaMe app demonstrated significantly better adherence outcomes (1.05±0.78) than the controls (2.92±1.4, P<0.001). The intervention group had significantly higher CDTAQ scores (185.5±8.07) than the control group (151.79±27.08, P<0.001).

Conclusion: The therapy reminder app significantly enhanced medication adherence and treatment management in patients with BTM, while simultaneously enhancing patient and family engagement through counseling.Trial Registration Number: IRCT20240222061079N1.

Abstract Image

治疗提醒应用对成人重度β -地中海贫血患者治疗依从性的影响:一项随机临床试验
背景:重度β -地中海贫血(BTM)患者的治疗依从性对有效的疾病管理提出了重大挑战。本研究旨在评估治疗提醒应用程序(app)对2024年马什哈德成年BTM患者治疗依从性的影响。方法:一项随机临床试验于2024年在马什哈德医学大学(伊朗马什哈德)附属地中海贫血诊所进行。采用分组随机法,将受试者随机分为干预组和对照组。干预组使用ThalaMe治疗提醒应用程序8周(2024年2月至7月),对照组接受标准治疗。干预前后采用Morisky药物依从性量表(MMAS-8)和慢性疾病治疗依从性问卷(CDTAQ)测量药物依从性。采用SPSS软件进行统计分析,组内比较采用配对t检验或Wilcoxon符号秩检验,组间比较采用独立t检验或Mann-Whitney U检验。结果:研究纳入76例成年BTM患者,平均分布于干预组和对照组(n=38)。基线测量结果显示,两组间MMAS-8评分(P=0.75)或CDTAQ评分(P=0.11)均无显著差异。MMAS-8得分相反,得分越低表明依从性越高。在8周的干预期后,使用ThalaMe应用程序组的依从性结果(1.05±0.78)明显优于对照组(2.92±1.4)。结论:治疗提醒应用程序显著提高了BTM患者的药物依从性和治疗管理,同时通过咨询提高了患者和家庭的参与度。试验注册号:IRCT20240222061079N1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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