The Role of Functional Polymorphisms of Apoptotic BAX (-248G>A) and Anti-Apoptotic BCL2 (-938C>A) Genes in the Development of Vitiligo: A Cross-sectional Study.

IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL
Afrooz Daneshparvar, Iman Jamhiri, Farhad Handjani, Nasrin Hamidizadeh
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引用次数: 0

Abstract

Background: Vitiligo is an autoimmune skin disorder in which apoptosis plays an exceptionally vital role in its occurrence. Research has shown a strong association between the presence of polymorphisms and the occurrence of diseases. This study aimed to determine the association of BAX-248G>A and BCL2-938C>A polymorphisms with vitiligo.

Methods: This cross-sectional study utilized the tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS PCR) in a cohort of vitiligo patients referred to the esteemed dermatology department of Shahid Faqihi Hospital in Shiraz between 2022 and 2023. The Chi square test and t test were used to analyze data, and logistic regression was employed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for vitiligo risk associated with BAX-248G>A, BCL2-938 C>A polymorphisms. P values<0.05 indicated statistical significance.

Results: From 112 healthy individuals and 107 vitiligo patients, our research uncovered a significant association between the C allele (BCL2-938C>A) and the chance of vitiligo, with the CC genotype increasing the risk of developing this disease (OR=2.59, 95% CI=1.66-4.05, P<0.001). We also found that in individuals with the GG genotype (BAX-248G>A), the risk of vitiligo is higher (OR=4.576, 95% CI=1.19-17.60, P=0.027). Parental kinship was strongly correlated with vitiligo (OR=1.83, 95% CI=1.00-3.33, P=0.048). Moreover, no significant association was observed between smoking and vitiligo.

Conclusion: The results showed that BCL2-938C>A and BAX-248G>A polymorphisms may play a role in the pathogenesis of vitiligo and can be used as prognosis markers. However, further studies in larger groups and different populations are needed.

Abstract Image

凋亡基因BAX (-248G>A)和抗凋亡基因BCL2 (-938C>A)功能多态性在白癜风发病中的作用:一项横断面研究
背景:白癜风是一种自身免疫性皮肤疾病,其中细胞凋亡在其发生中起着异常重要的作用。研究表明,多态性的存在与疾病的发生有着密切的联系。本研究旨在确定BAX-248G>A和BCL2-938C>A多态性与白癜风的关系。方法:本横断面研究采用四引物扩增难治性突变系统聚合酶链反应(ARMS PCR)对2022年至2023年在设拉子Shahid Faqihi医院皮肤科就诊的白癜风患者进行研究。采用卡方检验和t检验对数据进行分析,采用logistic回归计算BAX-248G>A、bcl2 - 938c >A多态性与白癜风风险的比值比(ORs)和95%置信区间(ci)。结果:在112名健康个体和107名白癜风患者中,我们的研究发现C等位基因(BCL2-938C> a)与白癜风发病几率存在显著相关性,CC基因型增加白癜风发病风险(OR=2.59, 95% CI=1.66-4.05, PBAX-248G> a),白癜风发病风险更高(OR=4.576, 95% CI=1.19-17.60, P=0.027)。亲本亲属关系与白癜风的相关性较强(OR=1.83, 95% CI=1.00-3.33, P=0.048)。此外,没有观察到吸烟和白癜风之间的显著关联。结论:BCL2-938C>A和BAX-248G>A多态性可能在白癜风发病中发挥作用,可作为预后指标。然而,需要在更大的群体和不同的人群中进行进一步的研究。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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