Technical Challenges in Studying Infectious Disease-Associated Pulmonary Hypertension in Low- and Middle-Income Countries with Limited Resources.

IF 2.4 Q2 INFECTIOUS DISEASES

Infectious Disease Reports Pub Date : 2025-09-10 DOI:10.3390/idr17050109

Jennifer van Heerden, Irina Mbanze, Elizabeth Louw, Olukayode Aremu, Anastase Dzudie, Ana Mocumbi, Threnesan Naidoo, Brian Allwood, Friedrich Thienemann

{"title":"Technical Challenges in Studying Infectious Disease-Associated Pulmonary Hypertension in Low- and Middle-Income Countries with Limited Resources.","authors":"Jennifer van Heerden, Irina Mbanze, Elizabeth Louw, Olukayode Aremu, Anastase Dzudie, Ana Mocumbi, Threnesan Naidoo, Brian Allwood, Friedrich Thienemann","doi":"10.3390/idr17050109","DOIUrl":null,"url":null,"abstract":"Background: Pulmonary hypertension (PH) disproportionately affects those residing in low- and middle-income countries (LMICs). Given that these countries also have a high prevalence of infectious diseases, many cases of PH are either directly or indirectly related to infectious etiologies. Despite this correlation, the precise burden of infectious disease-associated PH is largely underappreciated due to a lack of diagnostic resources, a shortage of clinical expertise to carry out right heart catheterization and poor access to healthcare facilities in many low- and middle-income settings.Methods: In this narrative review, we highlight the significant burden of infectious disease-associated PH in LMICs, outline the technical challenges faced by LMICs when diagnosing PH, and propose possible solutions for diagnosing PH in resource-constrained settings.Conclusions: Low-cost and sustainable solutions for infectious disease-associated PH in LMICs should be prioritized. Meaningful solutions require collaborative efforts and capacity building in LMICs.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 5","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452579/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious Disease Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/idr17050109","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Pulmonary hypertension (PH) disproportionately affects those residing in low- and middle-income countries (LMICs). Given that these countries also have a high prevalence of infectious diseases, many cases of PH are either directly or indirectly related to infectious etiologies. Despite this correlation, the precise burden of infectious disease-associated PH is largely underappreciated due to a lack of diagnostic resources, a shortage of clinical expertise to carry out right heart catheterization and poor access to healthcare facilities in many low- and middle-income settings.

Methods: In this narrative review, we highlight the significant burden of infectious disease-associated PH in LMICs, outline the technical challenges faced by LMICs when diagnosing PH, and propose possible solutions for diagnosing PH in resource-constrained settings.

Conclusions: Low-cost and sustainable solutions for infectious disease-associated PH in LMICs should be prioritized. Meaningful solutions require collaborative efforts and capacity building in LMICs.

查看原文本刊更多论文

资源有限的中低收入国家研究感染性疾病相关肺动脉高压的技术挑战

背景：肺动脉高压（PH）对低收入和中等收入国家（LMICs）人群的影响尤为严重。鉴于这些国家的传染病流行率也很高，许多PH病例直接或间接与传染病病因有关。尽管存在这种相关性，但由于缺乏诊断资源、缺乏开展右心导管术的临床专业知识以及在许多低收入和中等收入环境中难以获得医疗保健设施，传染病相关的PH的确切负担在很大程度上没有得到充分认识。方法：在这篇叙述性综述中，我们强调了中低收入国家与传染病相关的PH的重大负担，概述了中低收入国家在诊断PH时面临的技术挑战，并提出了在资源有限的情况下诊断PH的可能解决方案。结论：应优先考虑低成本和可持续的解决方案，以应对中低收入国家与传染病相关的PH。有意义的解决方案需要中低收入国家的合作努力和能力建设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊