Changzhen Li, Lei Xi, Jingjing Rao, Feng Tang, Yun Xiang, Xiaomei Wang
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引用次数: 0
Abstract
Objectives: To characterize the epidemiology of pediatric respiratory infections and evaluate the lagged, nonlinear associations between meteorological factors and pathogen activity in post-COVID-19 Wuhan, China.
Methods: A total of 28,903 respiratory specimens were collected from pediatric patients at a tertiary hospital between November 2023 and February 2025. Seven pathogens-Mycoplasma pneumoniae, adenovirus, respiratory syncytial virus (RSV), influenza A/B, and parainfluenza virus types I/III-were detected using multiplex RT-PCR. Epidemiological patterns were analyzed by age, sex, seasonality, and clinical setting. Daily meteorological data (temperature, relative humidity, wind speed) were aggregated citywide and temporally matched to case data. Spearman correlation and generalized additive models integrated with distributed lag nonlinear models (GAM-DLNMs) were used to assess pathogen-specific climatic sensitivity.
Results: M. pneumoniae (18.9%), adenovirus (14.5%), and RSV (9.1%) were the most prevalent pathogens. Distinct age- and sex-specific distributions were observed, with M. pneumoniae peaking in school-aged boys and RSV in infants. Seasonal peaks were evident: RSV and influenza A predominated in winter, while adenovirus peaked in spring. Meteorological analysis revealed pathogen-specific associations: low humidity preceded RSV surges by 7-14 days; influenza B was strongly associated with wind exposure; and extreme climatic conditions showed heterogeneous effects on transmission risk across pathogens.
Conclusions: This study demonstrates the utility of GAM-DLNMs in capturing climate-sensitive, time-lagged transmission dynamics for multiple pediatric respiratory pathogens. The findings support the development of localized, climate-informed early warning systems to enhance respiratory disease surveillance and preparedness.
期刊介绍：
Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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