Cognitive behavioral therapy for anxiety and depression symptoms in people of Parkinson's disease: a systematic review and meta-analysis.

IF 4.5 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1440850

Xing Yu, Qianhao Wu, Yuewen Liu, Peipei Han, Xiaoyu Chen, Qi Guo

{"title":"Cognitive behavioral therapy for anxiety and depression symptoms in people of Parkinson's disease: a systematic review and meta-analysis.","authors":"Xing Yu, Qianhao Wu, Yuewen Liu, Peipei Han, Xiaoyu Chen, Qi Guo","doi":"10.3389/fnagi.2025.1440850","DOIUrl":null,"url":null,"abstract":"Objectives: We aim to conducted a systematic review and meta-analysis of published RCTs (Randomized Controlled Trials, RCTs) to quantify the effects of CBT (Cognitive behavioral therapy, CBT), including both remote and in-person modalities, on anxiety, depressive symptoms, and QoL (Quality of Life, QoL) in people with PD (Parkinson's disease, PD).Methods: The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Eight databases were systematically searched for existing RCTs of CBT in people of PD published in English or Chinese. Searches were updated to February 29, 2024. Methodological quality was appraised with the Cochrane Risk of Bias tool. A meta-analysis of comparative effects was performed using the Review Manager v. 5.4 software.Results: 16 RCTs were included in the study. The studies involved a total of 682 participants, the mean age of participants ranged from 43 to 85. Depression scores of people in the CBT intervention group were significantly improved (SMD: -1.01, 95CI [-1.27, -0.74], P < 0.001), the overall meta-analysis result showed that the CBT group had significant improvement in anxiety compared to the control group (SMD: -2.00, 95CI [-2.74, -1.26], P < 0.001), results did not show a significant improvement in QoL in CBT group (SMD: -0.40, 95CI [-0.84, 0.04], P = 0.08).Conclusion: This systematic review and meta-analysis provide evidence that CBT intervention significantly improved anxiety and depression in People of PD compared to the control group, whether through offline or remote intervention. No improvement effect of CBT intervention on the QoL of People of PD was found. In the future application of telemedicine, interdisciplinary interventions should be explored to improve the motor and non-motor symptoms and QoL of People of PD.Systematic review registration: https://www.crd.york.ac.uk/prospero/#recordDetails. Identifier: CRD42024526608.","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1440850"},"PeriodicalIF":4.5000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447579/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2025.1440850","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: We aim to conducted a systematic review and meta-analysis of published RCTs (Randomized Controlled Trials, RCTs) to quantify the effects of CBT (Cognitive behavioral therapy, CBT), including both remote and in-person modalities, on anxiety, depressive symptoms, and QoL (Quality of Life, QoL) in people with PD (Parkinson's disease, PD).

Methods: The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Eight databases were systematically searched for existing RCTs of CBT in people of PD published in English or Chinese. Searches were updated to February 29, 2024. Methodological quality was appraised with the Cochrane Risk of Bias tool. A meta-analysis of comparative effects was performed using the Review Manager v. 5.4 software.

Results: 16 RCTs were included in the study. The studies involved a total of 682 participants, the mean age of participants ranged from 43 to 85. Depression scores of people in the CBT intervention group were significantly improved (SMD: -1.01, 95CI [-1.27, -0.74], P < 0.001), the overall meta-analysis result showed that the CBT group had significant improvement in anxiety compared to the control group (SMD: -2.00, 95CI [-2.74, -1.26], P < 0.001), results did not show a significant improvement in QoL in CBT group (SMD: -0.40, 95CI [-0.84, 0.04], P = 0.08).

Conclusion: This systematic review and meta-analysis provide evidence that CBT intervention significantly improved anxiety and depression in People of PD compared to the control group, whether through offline or remote intervention. No improvement effect of CBT intervention on the QoL of People of PD was found. In the future application of telemedicine, interdisciplinary interventions should be explored to improve the motor and non-motor symptoms and QoL of People of PD.

Systematic review registration: https://www.crd.york.ac.uk/prospero/#recordDetails. Identifier: CRD42024526608.

查看原文本刊更多论文

认知行为疗法治疗帕金森病患者焦虑和抑郁症状：系统回顾和荟萃分析

目的：我们旨在对已发表的随机对照试验（rct）进行系统回顾和荟萃分析，以量化认知行为疗法（CBT）对PD（帕金森病，PD）患者焦虑、抑郁症状和生活质量（QoL）的影响，包括远程和现场模式。方法：系统评价和荟萃分析遵循系统评价和荟萃分析首选报告项目（PRISMA）指南。系统检索了8个数据库，检索了现有的以英文或中文发表的PD患者CBT的随机对照试验。搜索更新到2024年2月29日。采用Cochrane偏倚风险工具评价方法学质量。使用Review Manager v. 5.4软件对比较效果进行meta分析。结果：共纳入16项rct。这些研究共涉及682名参与者，参与者的平均年龄从43岁到85岁不等。CBT干预组患者抑郁评分显著改善（SMD: -1.01, 95CI [-1.27, -0.74], P < 0.001），整体meta分析结果显示CBT组患者焦虑评分较对照组有显著改善（SMD: -2.00, 95CI [-2.74, -1.26], P < 0.001），结果显示CBT组患者生活质量无显著改善（SMD: -0.40, 95CI [-0.84, 0.04], P = 0.08）。结论：本系统综述和荟萃分析提供的证据表明，无论是通过离线干预还是远程干预，CBT干预均能显著改善PD患者的焦虑和抑郁。CBT干预对PD患者的生活质量无改善作用。在未来的远程医疗应用中，应探索跨学科的干预措施，以改善PD患者的运动和非运动症状和生活质量。系统评审注册：https://www.crd.york.ac.uk/prospero/#recordDetails。标识符:CRD42024526608。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.