The role of RNA binding proteins in regulating oocyte maturation

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-09-19 DOI:10.1016/j.cellsig.2025.112150

Lin Chen , Jing Chen

引用次数: 0

Abstract

Oocyte maturation is a complex and delicate process involving multiple gene expression levels. RNA-binding proteins (RBPs) are pivotal regulators in oocyte maturation and mRNA metabolism through spatiotemporal control of processing, stability, localization, and translational activation. This review synthesizes current knowledge on RBPs-mediated regulatory networks on oocyte maturation and their impacts on oocyte quality and reproductive health. The characteristics of RBPs across species are also discussed, establishing a conceptual framework for developing novel therapeutic strategies to improve female fertility.

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RNA结合蛋白在调节卵母细胞成熟中的作用。

卵母细胞成熟是一个复杂而微妙的过程，涉及多个基因表达水平。rna结合蛋白（rbp）是卵母细胞成熟和mRNA代谢的关键调节因子，通过时空控制加工、稳定、定位和翻译激活。本文综述了rbp介导的卵母细胞成熟调控网络及其对卵母细胞质量和生殖健康的影响。本文还讨论了rbp的跨物种特征，为开发新的治疗策略来提高女性生育能力建立了一个概念框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.