{"title":"Retrospective study on MRI accuracy in assessing liver fibrosis among patients with chronic liver disease.","authors":"Subha Santhoshi Vanka, Nikita Rao Nalla, Shaheed Shaik, Navneeth Jayaprakash, Mohammed Zakiullah Shareef, Sneha Mahalpure","doi":"10.6026/973206300211643","DOIUrl":null,"url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) is increasingly being utilized for the non-invasive liver fibrosis evaluation among chronic liver disease (CLD) patients. Therefore, it is of interest to assess the staging and diagnostic accuracy of MRI for liver fibrosis compared to histopathological outcome in 150 patients with CLD. MRI data were analyzed with advanced techniques such as elastography and T1/T2 mapping and these results were matched against fibrosis stages ascertained through biopsy. The sensitivity and specificity of MRI in detecting extensive fibrosis ≥F2 were 88% and 91%, respectively. Fibrosis scores determined by MRI were correlated with histopathological stage with r = 0.87, p < 0.01. The findings revealed MRI as an effective non-invasive modality for liver fibrosis that, complementarily, decreases the position of invasive biopsy in patients with CLD.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1643-1646"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449564/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211643","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Magnetic resonance imaging (MRI) is increasingly being utilized for the non-invasive liver fibrosis evaluation among chronic liver disease (CLD) patients. Therefore, it is of interest to assess the staging and diagnostic accuracy of MRI for liver fibrosis compared to histopathological outcome in 150 patients with CLD. MRI data were analyzed with advanced techniques such as elastography and T1/T2 mapping and these results were matched against fibrosis stages ascertained through biopsy. The sensitivity and specificity of MRI in detecting extensive fibrosis ≥F2 were 88% and 91%, respectively. Fibrosis scores determined by MRI were correlated with histopathological stage with r = 0.87, p < 0.01. The findings revealed MRI as an effective non-invasive modality for liver fibrosis that, complementarily, decreases the position of invasive biopsy in patients with CLD.
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