Hassan N. Al Hashem, Kaiwen Zhang, Amanda N. Abraham, Deepak Sharma, Andre Chambers, Mehrnoosh Moghaddar, Chayla L. Reeves, Sanjay K. Srivastava, Amy Gelmi, Arman Ahnood
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引用次数: 0
Abstract
The ability to form diamond electrodes on insulating polycrystalline diamond substrates using single-step laser patterning and the use of these electrodes as a substrate that supports the adhesion and proliferation of human mesenchymal stem cells (hMSCs) are demonstrated. Laser-induced graphitization results in a conductive amorphous carbon surface, rich in oxygen- and nitrogen-terminated groups. This leads to an electrode with a high specific capacitance of 182 μF cm2, a wide water window of 3.25 V, and a low electrochemical impedance of 129 Ω cm2 at 1 kHz—essential attributes for effective bioelectronic cell interfaces. The electrode's surface exhibits no cytotoxic responses with hMSCs, supporting cell adhesion and proliferation. Cells cultured on the electrode display significant elongation and alignment along the direction of the laser-patterned microgrooves—an additional modality for cellular modulation. The combination of favorable electrochemical performance and effective cellular control makes laser-patterned diamond electrodes a versatile platform in stem cell therapeutics. This direct fabrication approach paves the way for the integration of diamond electrodes in bioelectronic devices, offering new opportunities for tissue engineering and electroactive biomaterial applications.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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