The Efficiency of Plant Extracts in the Prevention of Gastric Cancer: A Systematic Review

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-09-22 DOI:10.1002/hsr2.71251

Mahsa Rezvan, Seyed Erfan Hossini, Kimia Sarmast, Faham Khamesipour

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Abstract

Background and Aims

Gastric cancer is a global health concern with high morbidity and mortality. This systematic review evaluates the potential of plant extracts in the prevention of gastric cancer by analyzing their bioactive mechanisms.

Methods

A total of 62 studies—including in vitro, in vivo, and clinical trials—were analyzed, focusing on their antiproliferative, proapoptotic, antiangiogenic, and anti-inflammatory properties.

Results

Extracts such as Marsdenia tenacissima, Curcuma longa, and Rhus verniciflua showed significant promise.

Conclusion

Despite these findings, issues surrounding bioavailability, dosing standardization, and long-term safety require further investigation before clinical translation.

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植物提取物对胃癌预防作用的系统综述

背景与目的胃癌是一种高发病率和高死亡率的全球性健康问题。本文通过分析植物提取物的生物活性机制，对其预防胃癌的潜力进行了系统评价。方法对62项体外、体内和临床研究进行分析，重点分析其抗增殖、促凋亡、抗血管生成和抗炎作用。结果马尾草、姜黄、漆树等提取物有较好的应用前景。结论：尽管有这些发现，但在临床转化之前，需要进一步研究生物利用度、剂量标准化和长期安全性等问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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