Potential Application Value of FASN in the Diagnosis of Colorectal Cancer

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-09-22 DOI:10.1002/jgh3.70261

Nan Li, Mingyue Hu, Qiliu Qian, Jun Ouyang, Yulin Yang, Yongqi Zhang

{"title":"Potential Application Value of FASN in the Diagnosis of Colorectal Cancer","authors":"Nan Li, Mingyue Hu, Qiliu Qian, Jun Ouyang, Yulin Yang, Yongqi Zhang","doi":"10.1002/jgh3.70261","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Fatty acid synthase (FASN) is a crucial enzyme that catalyzes endogenous lipogenesis in multiple diseases. However, the function and significance of FASN in colorectal cancer remain unclear.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>This research aimed to explore the expression and role of FASN in colorectal cancer.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Cancer, adjacent, and normal tissues were collected from patients with colorectal cancer and healthy controls. Immunohistochemistry and scoring were applied to analyze the expression of FASN in the different tissues, to investigate the differences in its expression among different tissue types, and to examine the potential correlation between FASN and gender, age, BMI, and other factors.</p>\n </section>\n \n <section>\n \n <h3> Discussion</h3>\n \n <p>In this study, 100 colorectal cancer patients and 100 healthy participants were recruited. Respectively, the average scores of cancer tissues, adjacent tissues, and normal tissues were 7.25, 2, and 1.25. Significant differences were found among these three tissue groups (<i>p</i> < 0.05). Moreover, no significant association was observed between sex, age, BMI, and FASN expression scores in colorectal cancer tissues (<i>p</i> > 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Based on these data, FASN was specifically overexpressed in cancer tissues and adjacent tissues. Hence, our results suggest that FASN may play an essential role in colorectal cancer and may be an attractive therapeutic target in the future.</p>\n </section>\n </div>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 9","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgh3.70261","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JGH Open","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jgh3.70261","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Fatty acid synthase (FASN) is a crucial enzyme that catalyzes endogenous lipogenesis in multiple diseases. However, the function and significance of FASN in colorectal cancer remain unclear.

Aims

This research aimed to explore the expression and role of FASN in colorectal cancer.

Results

Cancer, adjacent, and normal tissues were collected from patients with colorectal cancer and healthy controls. Immunohistochemistry and scoring were applied to analyze the expression of FASN in the different tissues, to investigate the differences in its expression among different tissue types, and to examine the potential correlation between FASN and gender, age, BMI, and other factors.

Discussion

In this study, 100 colorectal cancer patients and 100 healthy participants were recruited. Respectively, the average scores of cancer tissues, adjacent tissues, and normal tissues were 7.25, 2, and 1.25. Significant differences were found among these three tissue groups (p < 0.05). Moreover, no significant association was observed between sex, age, BMI, and FASN expression scores in colorectal cancer tissues (p > 0.05).

Conclusion

Based on these data, FASN was specifically overexpressed in cancer tissues and adjacent tissues. Hence, our results suggest that FASN may play an essential role in colorectal cancer and may be an attractive therapeutic target in the future.

查看原文本刊更多论文

FASN在结直肠癌诊断中的潜在应用价值

脂肪酸合成酶（FASN）是多种疾病中催化内源性脂肪生成的重要酶。然而，FASN在结直肠癌中的功能和意义尚不清楚。目的探讨FASN在结直肠癌中的表达及其作用。结果收集结直肠癌患者和健康对照者的癌组织、癌旁组织和正常组织。应用免疫组织化学和评分法分析FASN在不同组织中的表达，探讨FASN在不同组织类型中的表达差异，并探讨FASN与性别、年龄、BMI等因素的潜在相关性。本研究招募了100名结直肠癌患者和100名健康受试者。癌组织、癌旁组织和正常组织的平均评分分别为7.25分、2分和1.25分。三个组织组间差异有统计学意义（p < 0.05）。结直肠癌组织中，性别、年龄、BMI与FASN表达评分无显著相关性（p > 0.05）。结论FASN在癌组织及癌旁组织中特异性过表达。因此，我们的研究结果表明FASN可能在结直肠癌中发挥重要作用，并可能在未来成为一个有吸引力的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊