Tong Pan, Can-can Du, Ying-jian Zhang, Zhen-long Liu
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引用次数: 0
Abstract
Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation is an important novel post-translational modification (PTM) that can affect protein structure and function, playing a crucial role in signal transduction, gene expression and cellular metabolism. Lactylation participates in the progression of various diseases, such as tumours, heart failure, myocardial infarction, renal fibrosis and Alzheimer's disease. These studies suggest that lactylation may mediate metabolic reprogramming and enhance cellular plasticity, providing new entry points for developing therapeutic approaches. This review introduces the progress on various aspects of lactylation, including mechanisms, regulations and disease associations, aiming to provide valuable insights and inspiration for further exploration of protein modification networks.
期刊介绍：
The Journal of Cellular and Molecular Medicine serves as a bridge between physiology and cellular medicine, as well as molecular biology and molecular therapeutics. With a 20-year history, the journal adopts an interdisciplinary approach to showcase innovative discoveries.
It publishes research aimed at advancing the collective understanding of the cellular and molecular mechanisms underlying diseases. The journal emphasizes translational studies that translate this knowledge into therapeutic strategies. Being fully open access, the journal is accessible to all readers.
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