Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-09-21 DOI:10.1002/brb3.70889

Saar Kariv, Jeong Woo Choi, Mohsen Benam, Sahil Chilukuri, Amirreza Alijanpourotaghsara, Nader Pouratian

{"title":"Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review","authors":"Saar Kariv, Jeong Woo Choi, Mohsen Benam, Sahil Chilukuri, Amirreza Alijanpourotaghsara, Nader Pouratian","doi":"10.1002/brb3.70889","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>Magnetoencephalography (MEG) offers high temporal resolution and whole-brain spatial coverage, making it a powerful tool to study brain networks. This systematic review examines the use of MEG to study Parkinson's disease (PD) brain network dysfunction, providing an update on scientific advances and identifying knowledge gaps that can be addressed using MEG as a research platform.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>Five databases (Cochrane, Embase, PubMed, Scopus, and Web of Science) were systematically searched for MEG-based PD publications from October 2018 (the date of the latest search in the previous systematic review) to June 2025. We used the Joanna Briggs Institute (JBI) checklist to individually assess each paper for quality and relevancy.</p>\n </section>\n \n <section>\n \n <h3> Finding</h3>\n \n <p>Fifty-four publications were grouped into motor or cognitive domains. Motor resting-state studies were further categorized into four groups: (1) Cortical Pathophysiology and its Modulation by Therapies, (2) Basal Ganglia-Cortical (BGC) Network Pathophysiology and its Modulation by Therapies, (3) Temporal Dynamics, Aperiodicity, and Nonlinearity in PD, and (4) Clinical Utility of MEG. We highlight increases in cortical beta power in response to L-DOPA and its correlation with motor symptom improvement, the broad cortical distribution of beta-gamma phase-amplitude coupling (PAC) in PD and its link to motor symptoms, corticocortical connectivity modulation in response to different treatments, and the integration of MEG with local field potentials to study cortico-subcortical abnormalities. Temporal dynamics, such as cortical beta bursts and reduced functional repertoire, are explored, as well as aperiodic components and nonlinearities in the power spectrum in PD. Clinically, MEG shows promise in optimizing DBS, predicting L-DOPA response, and uncovering movement-related and cognitive pathophysiology in PD.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Key PD knowledge gaps that can be addressed using MEG are identified, including the need to characterize network temporal dynamics and signal interrelation in PD, the causal pathological mechanisms of the disease, and the response to different treatment modalities.</p>\n </section>\n </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70889","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Behavior","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/brb3.70889","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

Magnetoencephalography (MEG) offers high temporal resolution and whole-brain spatial coverage, making it a powerful tool to study brain networks. This systematic review examines the use of MEG to study Parkinson's disease (PD) brain network dysfunction, providing an update on scientific advances and identifying knowledge gaps that can be addressed using MEG as a research platform.

Method

Five databases (Cochrane, Embase, PubMed, Scopus, and Web of Science) were systematically searched for MEG-based PD publications from October 2018 (the date of the latest search in the previous systematic review) to June 2025. We used the Joanna Briggs Institute (JBI) checklist to individually assess each paper for quality and relevancy.

Finding

Fifty-four publications were grouped into motor or cognitive domains. Motor resting-state studies were further categorized into four groups: (1) Cortical Pathophysiology and its Modulation by Therapies, (2) Basal Ganglia-Cortical (BGC) Network Pathophysiology and its Modulation by Therapies, (3) Temporal Dynamics, Aperiodicity, and Nonlinearity in PD, and (4) Clinical Utility of MEG. We highlight increases in cortical beta power in response to L-DOPA and its correlation with motor symptom improvement, the broad cortical distribution of beta-gamma phase-amplitude coupling (PAC) in PD and its link to motor symptoms, corticocortical connectivity modulation in response to different treatments, and the integration of MEG with local field potentials to study cortico-subcortical abnormalities. Temporal dynamics, such as cortical beta bursts and reduced functional repertoire, are explored, as well as aperiodic components and nonlinearities in the power spectrum in PD. Clinically, MEG shows promise in optimizing DBS, predicting L-DOPA response, and uncovering movement-related and cognitive pathophysiology in PD.

Conclusion

Key PD knowledge gaps that can be addressed using MEG are identified, including the need to characterize network temporal dynamics and signal interrelation in PD, the causal pathological mechanisms of the disease, and the response to different treatment modalities.

Abstract Image

查看原文本刊更多论文

脑磁图技术在帕金森病研究中的应用综述

目的脑磁图（MEG）具有高时间分辨率和全脑空间覆盖能力，是研究脑网络的有力工具。本系统综述探讨了脑磁图在帕金森病（PD）脑网络功能障碍研究中的应用，提供了最新的科学进展，并确定了使用脑磁图作为研究平台可以解决的知识空白。方法系统检索5个数据库（Cochrane、Embase、PubMed、Scopus和Web of Science），检索2018年10月（上一篇系统综述中最新检索日期）至2025年6月基于meg的PD出版物。我们使用乔安娜布里格斯研究所（JBI）的检查表来单独评估每篇论文的质量和相关性。54份出版物被分为运动或认知领域。运动静息状态研究进一步分为四组：(1)皮质病理生理及其治疗调节；(2)基底神经节-皮质（BGC）网络病理生理及其治疗调节；(3)PD的时间动力学、非周期性和非线性；(4)脑磁图的临床应用。我们强调了左旋多巴后皮质β能量的增加及其与运动症状改善的相关性，PD中β - γ相幅耦合（PAC）的广泛皮质分布及其与运动症状的联系，不同治疗后皮质皮质连通性的调节，以及脑磁图与局部场电位的整合以研究皮质-皮质下异常。时间动力学，如皮层β爆发和减少的功能库，以及非周期成分和非线性功率谱的PD进行了探讨。在临床上，MEG有望优化DBS，预测左旋多巴反应，揭示PD的运动相关和认知病理生理。通过脑磁图识别PD的关键知识空白，包括表征PD的网络时间动态和信号相互关系的需要，疾病的因果病理机制，以及对不同治疗方式的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

期刊介绍： Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)