Amlodipine-Based Therapy and Its Effect on Time in Target Range and Long-Term Blood Pressure Variability Across Age Groups in Chinese Patients With Primary Hypertension: A Retrospective Study

IF 2.5 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Jinghan Yang, Shuling Chen, Dajun Chai, Feng Peng, Ningling Sun, Jinxiu Lin
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Abstract

This study aimed to compare systolic blood pressure (SBP) time in target range (TTR), long-term blood pressure (BP) variability (BPV), and BP control across age groups (18–45, 46–64, 65–79, ≥80 years) in patients with primary hypertension treated with amlodipine-based antihypertensive therapy for ≥12 months. Data were obtained from adult patients enrolled in the China Hypertension Center who received amlodipine-based antihypertensive therapy. Demographics, BP measurements, and laboratory results were recorded. Baseline characteristics, SBP TTR, long-term BPV, and BP control were compared among age groups. A total of 36 153 patients were included: 2681 in the 18–45 group, 14 300 in the 46–64 group, 15 595 in the 65–79 group, and 3577 in the ≥ 80 group. Younger and middle-aged patients demonstrated better indicator improvements. SBP TTR declined with age (82.52% ± 19.68%, 81.98% ± 20.69%, 79.10% ± 22.96%, and 78.33% ± 23.50%, respectively; p < 0.001). BP control also declined with age (84.04%, 83.20%, 80.44%, and 79.59%, respectively; p < 0.001). BPV increased with age, though not significantly (p = 0.051). During follow-up, SBP TTR and BP control improved, while BPV declined, with most changes reaching statistical significance. Across all age groups, SBP TTR remained above 78% throughout follow-up. Long-term continuous use of amlodipine is beneficial for achieving improved BP control, enhanced TTR, and reduced BPV.

基于氨氯地平的治疗及其对中国原发性高血压患者靶区时间和各年龄组长期血压变异性的影响:一项回顾性研究
本研究旨在比较不同年龄组(18-45岁、46-64岁、65-79岁、≥80岁)接受氨氯地平降压治疗≥12个月的原发性高血压患者的收缩压(SBP)目标范围时间(TTR)、长期血压(BP)变异性(BPV)和血压控制。数据来自于中国高血压中心登记的接受氨氯地平为基础的降压治疗的成年患者。记录人口统计学、血压测量和实验室结果。各组患者的基线特征、收缩压TTR、长期BPV和血压控制比较。共纳入36 153例患者:18-45岁组2681例,46-64岁组14300例,65-79岁组15595例,≥80岁组3577例。年轻和中年患者表现出较好的指标改善。收缩压TTR随年龄下降(分别为82.52%±19.68%、81.98%±20.69%、79.10%±22.96%、78.33%±23.50%,p < 0.001)。血压控制率也随年龄的增长而下降(分别为84.04%、83.20%、80.44%和79.59%,p < 0.001)。BPV随年龄增长而增加,但不显著(p = 0.051)。随访期间,收缩压TTR和血压控制改善,BPV下降,多数变化具有统计学意义。在所有年龄组中,收缩压TTR在随访期间保持在78%以上。长期持续使用氨氯地平有利于改善血压控制,增强TTR,降低BPV。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Hypertension
Journal of Clinical Hypertension PERIPHERAL VASCULAR DISEASE-
CiteScore
5.80
自引率
7.10%
发文量
191
审稿时长
4-8 weeks
期刊介绍: The Journal of Clinical Hypertension is a peer-reviewed, monthly publication that serves internists, cardiologists, nephrologists, endocrinologists, hypertension specialists, primary care practitioners, pharmacists and all professionals interested in hypertension by providing objective, up-to-date information and practical recommendations on the full range of clinical aspects of hypertension. Commentaries and columns by experts in the field provide further insights into our original research articles as well as on major articles published elsewhere. Major guidelines for the management of hypertension are also an important feature of the Journal. Through its partnership with the World Hypertension League, JCH will include a new focus on hypertension and public health, including major policy issues, that features research and reviews related to disease characteristics and management at the population level.
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