Rebecca Langhorn, Maiken B. T. Bach, Anne Sofie Gravgaard, Nanna Graversen, Caroline L. Olsen, Karoline H. Monrad, Jørgen Koch, Anders S. Schrøder, Jakob L. Willesen, Annemarie T. Kristensen, Lise N. Nielsen
{"title":"Applicability of Global Hemostatic Tools for Evaluation of Hemostatic State and Detection of Thrombosis in Cats With Cardiomyopathies","authors":"Rebecca Langhorn, Maiken B. T. Bach, Anne Sofie Gravgaard, Nanna Graversen, Caroline L. Olsen, Karoline H. Monrad, Jørgen Koch, Anders S. Schrøder, Jakob L. Willesen, Annemarie T. Kristensen, Lise N. Nielsen","doi":"10.1111/jvim.70250","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Arterial thromboembolism (ATE) is a known complication of cardiomyopathies (CM) in cats. Hypercoagulability is believed to be one predisposing factor.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>Assess applicability of global hemostatic tests for evaluating the systemic hemostatic state in cats with CM with concurrent ATE (CM + ATE).</p>\n </section>\n \n <section>\n \n <h3> Animals</h3>\n \n <p>Six cats with CM + ATE, 11 cats with CM, and 13 healthy cats.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Prospective case–control study (2016–2020). Echocardiography, whole blood thromboelastography (TEG), and thrombin generation testing (TGT) were performed. Hypercoagulability was defined for TEG as shortened reaction time (R), shortened kinetics (K), increased angle, or increased maximal amplitude and for TGT as decreased lag time, decreased time to peak, increased peak, or increased endogenous thrombin potential (ETP). If ≥ 1 parameter showed significant hypercoagulability compared with healthy cats, and no parameter showed significant hypocoagulability, the patient was considered hypercoagulable. The opposite criteria defined hypocoagulability.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Hypocoagulability was detected for cats with CM + ATE compared with both cats with CM and healthy cats, characterized by significantly prolonged R and K on TEG as well as significantly increased time-to-peak and decreased peak and ETP on TGT. Additionally, some thrombocytopenia was considered likely in cats with CM + ATE, but could not be fully evaluated because of a high prevalence of concurrent platelet aggregation.</p>\n </section>\n \n <section>\n \n <h3> Conclusions and Clinical Importance</h3>\n \n <p>A systemic hypocoagulable state was detected in cats with CM with concurrent ATE. Similar hemostatic paradoxes in human patients with thrombosis have been suggested to be related to platelet exhaustion, local endocardial hypercoagulability, or alterations in regulatory proteins.</p>\n </section>\n </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70250","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Internal Medicine","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jvim.70250","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Arterial thromboembolism (ATE) is a known complication of cardiomyopathies (CM) in cats. Hypercoagulability is believed to be one predisposing factor.
Objective
Assess applicability of global hemostatic tests for evaluating the systemic hemostatic state in cats with CM with concurrent ATE (CM + ATE).
Animals
Six cats with CM + ATE, 11 cats with CM, and 13 healthy cats.
Methods
Prospective case–control study (2016–2020). Echocardiography, whole blood thromboelastography (TEG), and thrombin generation testing (TGT) were performed. Hypercoagulability was defined for TEG as shortened reaction time (R), shortened kinetics (K), increased angle, or increased maximal amplitude and for TGT as decreased lag time, decreased time to peak, increased peak, or increased endogenous thrombin potential (ETP). If ≥ 1 parameter showed significant hypercoagulability compared with healthy cats, and no parameter showed significant hypocoagulability, the patient was considered hypercoagulable. The opposite criteria defined hypocoagulability.
Results
Hypocoagulability was detected for cats with CM + ATE compared with both cats with CM and healthy cats, characterized by significantly prolonged R and K on TEG as well as significantly increased time-to-peak and decreased peak and ETP on TGT. Additionally, some thrombocytopenia was considered likely in cats with CM + ATE, but could not be fully evaluated because of a high prevalence of concurrent platelet aggregation.
Conclusions and Clinical Importance
A systemic hypocoagulable state was detected in cats with CM with concurrent ATE. Similar hemostatic paradoxes in human patients with thrombosis have been suggested to be related to platelet exhaustion, local endocardial hypercoagulability, or alterations in regulatory proteins.
期刊介绍：
The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
