Development of two ion-selective sensors for determining benzydamine hydrochloride in the presence of its oxidative degradant across various matrices: greenness, whiteness, and blueness appraisals

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

BMC Chemistry Pub Date : 2025-09-23 DOI:10.1186/s13065-025-01625-9

Khadiga M. Kelani, Ragab A. M. Said, Mohammad A. El‑Dosoky, Lobna M. Abd El Halim, Ahmed R. Mohamed

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Abstract

Two sensitive and selective ion-selective electrodes (ISEs) were developed for the determination of benzydamine hydrochloride (BNZ·HCl): a conventional polyvinyl chloride (PVC) electrode and a coated graphite all solidstate ion-selective electrode (ASS-ISE). Both sensors were constructed using an ion-pair formed between BNZ⁺ and the lipophilic anion tetraphenylborate (TPB⁻), incorporated into the sensing membranes. The sensors exhibited near-Nernstian responses with slopes of 58.09 And 57.88 mV/decade, over a Linear range of 10^–5–10^–2 M, and detection Limits of 5.81 × 10^–8M and 7.41 × 10^–8 M, respectively. They demonstrated high accuracy and precision for the determination of BNZ·HCl in pure form, pharmaceutical cream, and biological fluids, with no matrix interference. The method also proved stability-indicating, successfully detecting BNZ·HCl in the presence of its oxidative degradant. Validation was performed according to ICH guidelines, and the method showed strong environmental compatibility based on greenness, whiteness, and blueness assessments, supporting its suitability for sustainable pharmaceutical analysis.

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两种离子选择性传感器的开发，用于测定盐酸苄胺在不同基质中氧化降解物的存在：绿度、白度和蓝度评价

建立了测定盐酸苄胺（BNZ·HCl）的两种灵敏选择性离子选择电极（ISEs）：常规聚氯乙烯（PVC）电极和涂覆石墨全固态离子选择电极（as - ise）。这两种传感器都是用BNZ⁺和亲脂阴离子四苯硼酸盐（TPB⁻）形成的离子对构建的，并结合在传感膜上。在10-5-10-2 M的线性范围内，传感器的响应斜率分别为58.09和57.88 mV/ 10年，检测限分别为5.81 × 10-8M和7.41 × 10-8 M。结果表明，该方法具有较高的准确度和精密度，可用于测定纯形式、药膏和生物液体中的BNZ·HCl，且无基质干扰。该方法也证明了稳定性，成功地检测了BNZ·HCl存在氧化降解的情况。根据ICH指南进行验证，基于绿度、白度和蓝度评估，该方法具有很强的环境兼容性，支持其可持续药物分析的适用性。

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来源期刊

BMC Chemistry Chemistry-General Chemistry

CiteScore

5.30

自引率

2.20%

发文量

审稿时长

27 weeks

期刊介绍： BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.