Dual liver-heart transplantation for highly allosensitized heart failure patients

IF 2.2 4区医学 Q3 IMMUNOLOGY

Human Immunology Pub Date : 2025-09-22 DOI:10.1016/j.humimm.2025.111587

Shin Lin , Elaine Chou-Wu , Mark Sturdevant , Yiing Lin , Jay Pal , Idoia Gimferrer

引用次数: 0

Abstract

Studies have demonstrated that the liver acts as an immunologic sink when transplanted with another organ from the same donor. In this work, we review evidence of this phenomenon in kidney-liver and heart-liver transplantation. We then explore the pros and cons of this strategy as a way of helping to transplant end stage heart failure patients who are highly allosensitized but do not have severe liver disease. By considering this strategy in the context of alternative therapies, we explain the types of patients who may benefit from it.

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高度异体化心力衰竭患者的双肝心脏移植

研究表明，当肝脏与来自同一供体的另一个器官一起移植时，肝脏起着免疫水槽的作用。在这项工作中，我们回顾了这一现象在肾-肝和心脏-肝移植中的证据。然后，我们探讨了这种策略的利弊，作为一种帮助移植高度同种异体敏感但没有严重肝脏疾病的终末期心力衰竭患者的方法。通过在替代疗法的背景下考虑这种策略，我们解释了可能从中受益的患者类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Immunology 医学-免疫学

CiteScore

5.40

自引率

7.40%

发文量

107

审稿时长

12 days

期刊介绍： The journal''s scope includes understanding the genetic and functional mechanisms that distinguish human individuals in their immune responses to allografts, pregnancy, infections or vaccines as well as the immune responses that lead to autoimmunity, allergy or drug hypersensitivity. It also includes examining the distribution of the genes controlling these responses in populations. Research areas include: Studies of the genetics, genomics, polymorphism, evolution, and population distribution of immune-related genes Studies of the expression, structure and function of the products of immune-related genes Immunogenetics of susceptibility to infectious and autoimmune disease, and allergy The role of the immune-related genes in hematopoietic stem cell, solid organ, and vascularized composite allograft transplant Histocompatibility studies including alloantibodies, epitope definition, and T cell alloreactivity Studies of immunologic tolerance and pregnancy T cell, B cell, NK and regulatory cell functions, particularly related to subjects within the journal''s scope Pharmacogenomics and vaccine development in the context of immune-related genes Human Immunology considers immune-related genes to include those encoding classical and non-classical HLA, KIR, MIC, minor histocompatibility antigens (mHAg), immunoglobulins, TCR, BCR, proteins involved in antigen processing and presentation, complement, Fc receptors, chemokines and cytokines. Other immune-related genes may be considered. Human Immunology is also interested in bioinformatics of immune-related genes and organizational topics impacting laboratory processes, organ allocation, clinical strategies, and registries related to autoimmunity and transplantation.