Seroprevalence of Angiostrongylus cantonensis in suspected human angiostrongyliasis cases and clinical manifestations in a tertiary care hospital in Thailand: a retrospective 18-year longitudinal study

IF 3.1 Q2 PARASITOLOGY

Food and Waterborne Parasitology Pub Date : 2025-09-15 DOI:10.1016/j.fawpar.2025.e00290

Lakkhana Sadaow , Thidarat K. Prasongdee , Phuangphaka Sadee , Sureeporn Naonongwai , Patcharaporn Boonroumkaew , Rutchanee Rodpai , Oranuch Sanpool , Amnat Kitkhuandee , Verajit Chotmongkol , Kittisak Sawanyawisuth , Pewpan M. Intapan , Wanchai Maleewong

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引用次数: 0

Abstract

Human angiostrongyliasis, a foodborne parasitosis caused by Angiostrongylus cantonensis, is primarily characterized by eosinophilic meningitis (EOM), meningoencephalitis or myelitis. This study reports the seroprevalence of A. cantonensis among suspected cases of angiostrongyliasis and describes the clinical manifestations in patients with positive serological tests at a Thai tertiary care hospital over an 18-year period (2006–2023). Among 768 patients suspected of eosinophilic meningitis related to A. cantonensis infection, 353 (46 %) tested positive for A. cantonensis IgG antibodies. Most seropositive patients were from the northeast region of Thailand (308/353; 87.2 %). Among the seropositive patients, 13 % reported a history of consuming uncooked freshwater snails or other paratenic hosts. Headache was reported in 23.5 % of the patients, with 31.3 % (n = 26) experiencing acute severe headache. Fever and neck stiffness were present in 6.8 % and 6.5 % of the patients, respectively, while nausea and vomiting were observed in 7.9 %. In a subset of 56 seropositive patients who underwent lumbar puncture, cerebrospinal fluid (CSF) examination was clear in 49 (87.5 %), cloudy in six (10.7 %), and xanthochromic in one case (1.8 %). The highest recorded CSF opening pressure was 600 mmHg, with a median pressure of 210 mmHg. The average CSF white blood cell count was 200 cells/mm³ (range: 0–2250 cells/mm³), with eosinophils constituting an average of 35 % (range: 1–90 %). These findings may be useful for clinicians in endemic regions as supportive information for clinical diagnosis.

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泰国某三级医院怀疑人血管圆线虫病病例中广东管圆线虫的血清阳性率和临床表现：一项回顾性的18年纵向研究

人血管圆线虫病是一种由广东血管圆线虫引起的食源性寄生虫病，主要表现为嗜酸性脑膜炎（EOM）、脑膜脑炎或脊髓炎。本研究报告了18年间（2006-2023年）泰国一家三级医院疑似血管圆线虫病病例中广东棘球绦虫的血清阳性率，并描述了血清学检测阳性患者的临床表现。768例疑似广东单胞杆菌感染所致嗜酸性粒细胞性脑膜炎患者中，353例（46%）广东单胞杆菌IgG抗体阳性。大多数血清阳性患者来自泰国东北部地区（308/353;87.2%）。在血清呈阳性的患者中，13%报告有食用未煮熟的淡水蜗牛或其他副病原宿主的历史。23.5%的患者报告头痛，其中31.3% （n = 26）出现急性严重头痛。6.8%和6.5%的患者分别出现发热和颈部僵硬，而7.9%的患者出现恶心和呕吐。在56例行腰椎穿刺的血清阳性患者中，49例（87.5%）脑脊液（CSF）检查清晰，6例（10.7%）浑浊，1例（1.8%）黄色。最高记录的脑脊液开口压力为600 mmHg，中位压力为210 mmHg。脑脊液白细胞平均计数为200个细胞/mm3（范围：0-2250个细胞/mm3），嗜酸性粒细胞平均占35%（范围：1 - 90%）。这些发现可能对流行地区的临床医生有用，作为临床诊断的支持性信息。

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来源期刊

Food and Waterborne Parasitology Immunology and Microbiology-Parasitology

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Food and Waterborne Parasitology publishes high quality papers containing original research findings, investigative reports, and scientific proceedings on parasites which are transmitted to humans via the consumption of food or water. The relevant parasites include protozoa, nematodes, cestodes and trematodes which are transmitted by food or water and capable of infecting humans. Pertinent food includes products of animal or plant origin which are domestic or wild, and consumed by humans. Animals and plants from both terrestrial and aquatic sources are included, as well as studies related to potable and other types of water which serve to harbor, perpetuate or disseminate food and waterborne parasites. Studies dealing with prevalence, transmission, epidemiology, risk assessment and mitigation, including control measures and test methodologies for parasites in food and water are of particular interest. Evidence of the emergence of such parasites and interactions among domestic animals, wildlife and humans are of interest. The impact of parasites on the health and welfare of humans is viewed as very important and within scope of the journal. Manuscripts with scientifically generated information on associations between food and waterborne parasitic diseases and lifestyle, culture and economies are also welcome. Studies involving animal experiments must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences.