Altered neurovascular-cerebrospinal fluid synergy in chronic insomnia disorder

IF 3.4 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2025-09-19 DOI:10.1016/j.sleep.2025.106815

Shaoxiang Zhong , Yuan He , Kang Chen , Rui Qu , Weicheng Luo , Hongyu Zhang , Shang Zhang , Wenjun Zhou , Liang Gong

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引用次数: 0

Abstract

Background

Chronic insomnia disorder (CID) is associated with neurophysiological dysfunction; however, its effects on neurovascular and glymphatic interactions remain inadequately understood.

Methods

This study examined the coupling strength between global blood-oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow dynamics in CID patients (n = 137) and healthy controls (HC, n = 72) using resting state functional magnetic resonance imaging.

Results

Results demonstrated significantly diminished gBOLD-CSF coupling in CID patients compared to HC. Across all participants, coupling strength exhibited a negative correlation with age and a positive correlation with educational attainment. Counterintuitively, higher Pittsburgh Sleep Quality Index (PSQI) scores, indicative of poorer sleep quality, were associated with stronger BOLD-CSF coupling, potentially reflecting compensatory mechanisms during infrequent deep sleep episodes.

Conclusion

These findings underscore disrupted neurovascular-glymphatic communication in chronic insomnia, which may predispose individuals to neurodegenerative risks. This study highlights the necessity for reevaluating insomnia as a systemic threat to brain health, necessitating longitudinal investigations and therapeutic strategies targeting glymphatic preservation.

Abstract Image

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慢性失眠症中神经血管-脑脊液协同作用的改变

背景：慢性失眠障碍（CID）与神经生理功能障碍有关；然而，其对神经血管和淋巴相互作用的影响仍不充分了解。方法采用静息状态功能磁共振成像技术检测CID患者（n = 137）和健康对照（n = 72）的全血氧水平依赖（gBOLD）信号与脑脊液（CSF）流入动力学之间的耦合强度。结果显示，与HC相比，CID患者的gBOLD-CSF偶联显著降低。在所有参与者中，耦合强度与年龄呈负相关，与受教育程度呈正相关。与直觉相反的是，较高的匹兹堡睡眠质量指数（PSQI）分数表明较差的睡眠质量，与较强的BOLD-CSF耦合相关，可能反映了在不频繁的深度睡眠发作期间的代偿机制。结论这些发现强调了慢性失眠中神经血管-淋巴通讯的中断，这可能使个体易患神经退行性风险。这项研究强调了重新评估失眠对大脑健康的系统性威胁的必要性，需要纵向调查和针对淋巴细胞保存的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.