Lycium barbarum polysaccharide regulates serum metabolites in type 2 diabetic patients with the metabolomics-based approach of GC-TOF-MS

IF 7.2 Q1 FOOD SCIENCE & TECHNOLOGY

Journal of Future Foods Pub Date : 2025-05-03 DOI:10.1016/j.jfutfo.2024.12.001

Zixuan Zhu , Jing Sui , Huizhen Cai , Beijia Zhou , Bihuan Hu , Ying Wang , Daochen Gong , Shaokang Wang , Ligang Yang , Wang Liao , Guiju Sun , Hui Xia

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引用次数: 0

Abstract

Lycium barbarum polysaccharide (LBP) has displayed beneficial effects against type 2 diabetes (T2D), such as reducing blood glucose and lipids. We utilized a metabolomics method to explore the effects of LBP on the regulation of diabetes. Twenty T2D patients were included and provided with LBP (300 mg/d) for 3 months. LBP reduced the fasting blood glucose levels of participants after 3 months (P = 0.057) and significantly improved serum insulin-like growth factor binding protein (IGFBP) levels. In addition, LBP significantly regulated 24 serum metabolites, and the following KEGG pathway analysis indicated that LBP primarily affected glutamine and glutamate metabolism. Overall, LBP consumption influenced serum metabolites and displayed hypoglycemic effects by regulating the metabolic pathway modulating glutamine and glutamate.

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基于GC-TOF-MS代谢组学方法的枸杞多糖调节2型糖尿病患者血清代谢物

枸杞多糖（LBP）已显示出对2型糖尿病（T2D）的有益作用，如降低血糖和血脂。我们利用代谢组学方法来探讨LBP对糖尿病的调节作用。纳入20例T2D患者，给予LBP （300 mg/d）治疗3个月。LBP在3个月后降低了参与者的空腹血糖水平（P = 0.057），并显著提高了血清胰岛素样生长因子结合蛋白（IGFBP）水平。此外，LBP显著调节24种血清代谢物，随后的KEGG通路分析表明，LBP主要影响谷氨酰胺和谷氨酸代谢。总之，LBP消耗影响血清代谢物，并通过调节谷氨酰胺和谷氨酸的代谢途径发挥降糖作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Future Foods

CiteScore

5.80

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0.00%

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