Thiamin hydrochloride (VB1): A green and efficient catalyst for the synthesis of imidazolidin-4-ones

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-09-17 DOI:10.1080/00397911.2025.2550435

Chuang Liu (Writing – original draft Writing – review & editing) , Yang Zhou (Formal analysis Supervision) , Wenqiang Pei (Data curation Investigation) , Jinjun Hou (Formal analysis Supervision Validation) , Huali Long (Data curation Supervision) , Zijia Zhang (Conceptualization Supervision Validation) , Qinhua Chen (Funding acquisition Resources) , Yang Yang (Funding acquisition Investigation Resources) , Min Lei (Conceptualization Methodology Supervision Writing – original draft) , Wanying Wu (Funding acquisition Project administration Resources Supervision)

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引用次数: 0

Abstract

A green and efficient method for synthesizing imidazolidin-4-one derivatives catalyzed by thiamin hydrochloride (VB₁) has been developed. This protocol involves the reaction of α-amino amides with carbonyl compounds (aldehydes or ketones) in the presence of VB₁ (5 mol%) in EtOH, affording the target products in 50–85% yields. The reaction demonstrates broad substrate compatibility, accommodating aromatic aldehydes, heteroaromatic aldehydes, alkyl aldehydes, and alkyl ketones. Notably, estrone as a ketone substrate successfully undergoes condensation, yielding the corresponding product in 72% yield. The VB₁ catalyst offers advantages such as short reaction times, high efficiency, excellent environmental friendliness, and recyclability, maintaining performance over at least three cycles.

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盐酸硫胺素（VB1）：合成咪唑烷-4-酮的绿色高效催化剂

建立了一种绿色高效的以盐酸硫胺素（VB1）为催化剂合成咪唑烷-4-酮衍生物的方法。该方案涉及α-氨基酰胺与羰基化合物（醛类或酮类）在乙醚中VB1 （5 mol%）存在下的反应，以50-85%的收率提供目标产物。该反应具有广泛的底物相容性，可容纳芳香族醛、杂芳香族醛、烷基醛和烷基酮。值得注意的是，雌酮作为酮底物成功地进行了缩合，产率为72%。VB1催化剂具有反应时间短、效率高、环境友好、可循环利用等优点，至少可在三个循环中保持性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.