Salome M. Xavier , Hannah E. Jongsma , Charlotte Gayer-Anderson , Diego Quattrone , Sophie Blackmore , Ilaria Tarricone , Pierre-Michel Llorca , Eva Velthorst , Robin M. Murray , Peter B. Jones , James B. Kirkbride , Craig Morgan , Jean-Paul Selten , Els van der Ven , Srividya N. Iyer
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引用次数: 0
Abstract
Background
Compared with individual-level factors, macro-level exposures have received less attention in research on the increased risk of psychosis among ethnic minorities. We aimed to investigate the impact of migrant integration policies and area-level social deprivation on higher incidence rates among ethnic minorities.
Methods
This study, conducted between 2010 and 2015, analysed incidence data from five countries from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions [EU-GEI]. The total population was multiplied by the duration of case-ascertainment to estimate person-years. Cases with a non-organic psychotic disorder were included. Exposures included population group (based on self/parental region of origin/self-ascribed ethnicity) and area-level exposures including country-level migrant integration policies and regional-level proxies of social deprivation (percentages of unemployment, low education, owner-occupied houses, single person-households). Negative binomial mixed-effects regression models were fitted to calculate the association between individual and area-level exposures and incidence of psychotic disorders.
Results
The study included 1933 individuals. Supportive migrant policies (IRR: 0.71; 95 % CI 0.68–0.73) and higher percentages of owner-occupied houses (IRR: 0.97; 95 % CI 0.96–0.97) were associated with lower incidence of psychosis. Higher percentages of unemployment (IRR: 1.08; 95 % CI 1.07–1.09) and single person-households (IRR: 1.10; 95 % CI 1.05–1.14) were associated with higher incidence of psychosis. Accounting for policies and area-level social deprivation markers reduced risk estimates among all migrant/ethnic minority groups, compared to the majority population.
Conclusions
This is the first study on the impact of migrant integration policies on psychosis incidence. Migrant integration policies and area-level social deprivation influenced psychosis risk in the overall and minority populations. These findings can inform policies and social epidemiological approaches to studying multi-level exposures in psychosis.
背景与个体水平因素相比,宏观水平暴露在少数民族精神病发病风险的研究中受到的关注较少。我们的目的是调查移民融合政策和地区层面的社会剥夺对少数民族较高发病率的影响。方法本研究于2010年至2015年间进行,分析了来自欧洲国家精神分裂症网络研究基因-环境相互作用[EU-GEI]的五个国家的发病率数据。总人数乘以病例确定的持续时间来估计人年。包括非器质性精神障碍的病例。暴露包括人口群体(基于自我/父母原籍地区/自我归属的种族)和区域水平暴露,包括国家层面的移民融合政策和区域层面的社会剥夺指标(失业率、低教育程度、自有住房、单身家庭的百分比)。采用负二项混合效应回归模型计算个体和区域暴露与精神障碍发病率之间的关系。研究对象包括1933人。支持性移民政策(IRR: 0.71; 95% CI 0.68-0.73)和较高的自有住房比例(IRR: 0.97; 95% CI 0.96-0.97)与较低的精神病发病率相关。较高的失业率(内部比值比:1.08;95% CI 1.07-1.09)和单身家庭(内部比值比:1.10;95% CI 1.05-1.14)与较高的精神病发病率相关。与大多数人口相比,考虑到政策和地区层面的社会剥夺标志降低了所有移民/少数民族群体的风险估计。结论本文首次研究了移民融合政策对精神病发病率的影响。移民融合政策和地区层面的社会剥夺影响总体和少数人群的精神病风险。这些发现可以为研究精神病多层次暴露的政策和社会流行病学方法提供信息。