Recent progress of manipulating microenvironment for spinal cord injury therapy using nanoparticles

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design Pub Date : 2025-09-15 DOI:10.1016/j.matdes.2025.114769

Linfeng Xiao, Chunping Tian, Yinshan Hong, Jiajun Wu, Jiani Du, Yanling Yang, Xiaowei Chang

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Abstract

Spinal cord injury (SCI) is a severe traumatic condition that profoundly compromises patients’ health and quality of life. While various therapeutic strategies, including pharmacotherapy, have been developed and demonstrate some efficacy, however their clinical application is significantly limited by challenges, such as low drug bioavailability and undesirable side effects. Moreover, a critical limitation is their frequently neglect the SCI microenvironment, which serves as the essential foundation for nerve regeneration. In contrast, intelligent nanoparticles-based delivery systems, owing to their excellent biocompatibility and high drug-loading capacity, they can modulate the SCI microenvironment on demand, hold great promise for improving SCI therapy. However, how to design intelligent nanoparticles to achieve precise microenvironment regulation for SCI therapy is still lack of a systematic summary. Therefore, this review summarizes recent advances in advances in modulating the microenvironment for treating SCI using targeted nano drug delivery system, hope provide a theoretical basis for the further development of nano-drug to treatment of SCI.

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纳米颗粒操纵微环境治疗脊髓损伤的研究进展

脊髓损伤是一种严重的创伤性疾病，严重影响患者的健康和生活质量。虽然包括药物治疗在内的各种治疗策略已经开发出来并显示出一定的疗效，但它们的临床应用受到诸如药物生物利用度低和不良副作用等挑战的严重限制。此外，一个关键的限制是他们经常忽视脊髓损伤微环境，这是神经再生的重要基础。相比之下，基于纳米颗粒的智能递送系统由于其优异的生物相容性和高载药能力，可以按需调节脊髓损伤微环境，在改善脊髓损伤治疗方面具有很大的希望。然而，如何设计出智能纳米颗粒来实现对脊髓损伤治疗的精确微环境调控，目前还缺乏系统的总结。因此，本文综述了近年来利用靶向纳米药物递送系统调节微环境治疗脊髓损伤的研究进展，希望为进一步开发纳米药物治疗脊髓损伤提供理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials & Design Engineering-Mechanical Engineering

CiteScore

14.30

自引率

7.10%

发文量

1028

审稿时长

85 days

期刊介绍： Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.