Oxygen self-supplied BTOv-Ru heterojunction boosts the sonodynamic antibacterial efficiency of scaffold

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-09-20 DOI:10.1016/j.colsurfb.2025.115153

Wenjie Ma , Ru Jia , Huixing Li , Lanlan Dong , Wurikaixi Aiyiti , Cijun Shuai , Chongxian He

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引用次数: 0

Abstract

Transplantation-related bacterial infections often slow new tissue regeneration and even cause transplant failure. Sonodynamic therapy is a promising antibacterial method, which kills bacteria by triggering sonosensitizers to generate reactive oxygen species (ROS). Nevertheless, the generation efficiency of ROS is hindered by the fast electron-hole pair recombination in sonosensitizers and the hypoxic of bacteria microenvironment. Herein, ruthenium nanoparticles (Ru NPs) are grown in-situ on the oxygen vacancies-rich barium titanate nanoparticles (BTOv NPs) to form a Schottky heterojunction. The resulting BTOv-Ru NPs as sonosensitizers is uniformly distributed with poly-L-lactic acid (PLLA) powders to fabricate ultrasound-responsive scaffolds via selective laser sintering. On the one hand, the Schottky heterojunction facilitates electron injection from BTOv to Ru, while the resultant charge separation significantly suppresses electron-hole recombination. On the other hand, the catalase-like activity of Ru catalyzes the overexpressed hydrogen peroxide to generate O₂ to achieve O₂ self-supply. This not only alleviates hypoxia but also facilitates the oxygen vacancies of BTOv adsorb more O₂ to generate ROS. The results confirmed PLLA/BTOv-Ru scaffold generated numerous ROS and exhibited excellent antibacterial effects under ultrasonic irradiation, with inhibiting E. coli (89.3 %) and S. aureus (88.1 %). This O₂ self-supplying sonodynamic therapy shows great promise in antibacterial treatment.

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氧自供BTOv-Ru异质结提高了支架的声动力抗菌效率

与移植相关的细菌感染往往会减缓新组织的再生，甚至导致移植失败。声动力疗法是一种很有前途的抗菌方法，它通过触发声敏剂产生活性氧（ROS）来杀死细菌。然而，声敏剂中电子-空穴对的快速重组和细菌微环境的缺氧阻碍了ROS的生成效率。本文将钌纳米粒子（Ru NPs）生长在富氧空位的钛酸钡纳米粒子（BTOv NPs）上，形成肖特基异质结。所得的BTOv-Ru NPs作为声敏剂均匀分布于聚l -乳酸（PLLA）粉末中，通过选择性激光烧结制备超声响应支架。一方面，肖特基异质结促进了电子从BTOv向Ru的注入，而由此产生的电荷分离显著抑制了电子-空穴复合。另一方面，Ru具有类似过氧化氢酶的活性，催化过表达的过氧化氢生成O2，实现O2的自供。这不仅缓解了缺氧，而且有利于BTOv的氧空位吸附更多的O2生成ROS。结果证实PLLA/BTOv-Ru支架在超声照射下产生大量活性氧，并表现出良好的抗菌效果，对大肠杆菌（89.3% %）和金黄色葡萄球菌（88.1 %）具有抑制作用。这种氧气自供声动力疗法在抗菌治疗中显示出很大的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.