Ozonated olive oil inhibits melanoma proliferation by inducing ferroptosis

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Seong-Jin An , Jun-Ichi Kashiwakura , Akira Katsuyama , Sumihito Togi , Yuichi Kitai , Ryuta Muromoto , Toshiaki Miura , Satoshi Ichikawa , Tadashi Matsuda
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引用次数: 0

Abstract

Although ozone is a potent oxidant that can damage lungs and skin after prolonged exposure, ozonated olive oil (OZO) exhibits antimicrobial, anti-inflammatory, and wound-healing effects. Here, we describe a novel application of OZO in melanoma therapy. Treatment with OZO markedly inhibited the proliferation of both human and murine melanoma cells, while sparing normal human keratinocyte. At the molecular level, OZO upregulated ferroptosis-related genes, decreased intracellular glutathione (GSH) and GPX4 protein levels and accelerated lipid peroxidation. Critically, OZO-induced growth inhibition in melanoma cells was prevented by ferroptosis inhibitors (ferrostatin-1 and deferiprone), but not by inhibitors of apoptosis or necroptosis. Taken together, these findings offer new therapeutics strategy for treating melanoma by inducing ferroptosis.
臭氧化橄榄油通过诱导铁下垂抑制黑色素瘤增殖
虽然臭氧是一种强效氧化剂,在长时间接触后会损害肺部和皮肤,但臭氧化橄榄油(OZO)具有抗菌、抗炎和伤口愈合的作用。在这里,我们描述了OZO在黑色素瘤治疗中的新应用。OZO治疗显著抑制了人和小鼠黑色素瘤细胞的增殖,同时保留了正常的人角质细胞。在分子水平上,OZO上调铁中毒相关基因,降低细胞内谷胱甘肽(GSH)和GPX4蛋白水平,加速脂质过氧化。关键的是,ozo诱导的黑色素瘤细胞生长抑制可以被铁抑制素(铁抑素-1和去铁素)所阻止,但不能被细胞凋亡或坏死抑制素所阻止。综上所述,这些发现为通过诱导铁下垂治疗黑色素瘤提供了新的治疗策略。
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来源期刊
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
4.60
自引率
0.00%
发文量
191
审稿时长
59 days
期刊介绍: Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.
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