Vascularizing stem cell-derived islets: A blueprint for functional maturation

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-09-22 DOI:10.1016/j.devcel.2025.07.012

Yan Xiong, Per-Olof Berggren

引用次数: 0

Abstract

In this issue of Developmental Cell, Jun, Nguyen-Ngoc et al. report that embedding human pluripotent stem cell-derived islets with endothelial cells and fibroblasts, which form perfusable microvessels, accelerates β cell functional maturation. Endothelial cell-derived extracellular matrix proteins and BMP2/4 enhance the β cell Ca²⁺ response, insulin secretion, and in vivo graft performance.

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血管干细胞衍生的胰岛：功能成熟的蓝图

在这一期的《发育细胞》杂志上，Jun、Nguyen-Ngoc等人报道，将人类多能干细胞衍生的胰岛与内皮细胞和成纤维细胞结合，形成可灌注的微血管，加速了β细胞的功能成熟。内皮细胞来源的细胞外基质蛋白和BMP2/4增强了β细胞Ca2 +的响应、胰岛素分泌和体内移植性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.