An Improved Synthesis of Ionizable Lipids D-Lin-KC2-DMA and D-Lin-MC3-DMA

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-09-21 DOI:10.1002/ejoc.202500592

Ardalan Nabi, Huy Tran, Fariba Saadati, Nagavenkata Durga Prasad Atmuri, Gregory Dake, Marco A. Ciufolini

引用次数: 0

Abstract

A new route to ionizable lipid KC2 through the double alkylation of TosMIC with linoleyl tosylate avoids problematic reactions, is higher yielding, and requires three fewer steps. Lipid MC3 is also more efficiently prepared by the new method.

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可电离脂质D-Lin-KC2-DMA和D-Lin-MC3-DMA的改进合成

通过TosMIC和tosylate亚油基的双烷基化，一种新的可电离脂质KC2的途径避免了有问题的反应，收率更高，并且需要更少的三个步骤。脂质MC3的制备效率也更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.