Lanthanide(III)-binding peptides and proteins: coordination properties and applications.

IF 39 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Enrico Falcone,Emilie Mathieu,Christelle Hureau
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引用次数: 0

Abstract

Lanthanides play a crucial role in modern medicine and technology as well as in the metabolism of methylotrophic bacteria. In this context, the research on lanthanide-binding peptides and proteins is an active and rapidly developing field. This comprehensive and critical review focuses on the structural, thermodynamic (affinity and selectivity) and kinetic parameters governing the interaction of Ln3+ ions with different peptides and proteins, including both naturally occurring and de novo-designed scaffolds. It thus provides guidelines and future directions for the rational design of Ln-binding peptides and proteins with suitable features for the main applications explored to date, including luminescent sensing, magnetic resonance imaging, Ln separation and recovery and Ln-based (photo)-catalysis.
镧系(III)结合肽和蛋白质:配位性质和应用。
镧系元素在现代医学和技术以及甲基营养细菌的代谢中发挥着至关重要的作用。在此背景下,镧系结合肽和蛋白质的研究是一个活跃而迅速发展的领域。这篇全面而批判性的综述侧重于Ln3+离子与不同肽和蛋白质相互作用的结构、热力学(亲和性和选择性)和动力学参数,包括天然存在的和新设计的支架。因此,它为合理设计具有合适特征的镧结合肽和蛋白提供了指导和未来方向,以适应迄今为止探索的主要应用,包括发光传感、磁共振成像、镧分离和回收以及镧基(光)催化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Society Reviews
Chemical Society Reviews 化学-化学综合
CiteScore
80.80
自引率
1.10%
发文量
345
审稿时长
6.0 months
期刊介绍: Chemical Society Reviews is published by: Royal Society of Chemistry. Focus: Review articles on topics of current interest in chemistry; Predecessors: Quarterly Reviews, Chemical Society (1947–1971); Current title: Since 1971; Impact factor: 60.615 (2021); Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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